Chitosan gallate as potential antioxidant biomaterial

被引：29
作者：
Cho, Young-Sook [3 ]
Kim, Se-Kwon [1 ,2 ]
Je, Jae-Young [3 ]
机构：
[1] Pukyong Natl Univ, Dept Chem, Pusan 608737, South Korea
[2] Pukyong Natl Univ, Marine Bioproc Res Ctr, Pusan 608737, South Korea
[3] Chonnam Natl Univ, Sch Food Technol & Nutr, Yeosu 550749, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 10期
关键词：
Chitosan; Gallic acid; Antioxidant activity; ROS; DNA damage; LIPID-PEROXIDATION; FLUORESCENT-PROBE; OXIDATION; RADICALS; DAMAGE;
D O I：
10.1016/j.bmcl.2011.03.033
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Chitosan gallate were synthesized using a free radical-induced grafting reaction. Chitosan gallate showed enhanced water-solubility compared to plain chitosan, and exhibited good thermal stability. The IC50 value of chitosan gallate against 2,2-diphenyl-1-picrylhydrazyl (DPPH) was 17.86 mu g/mL. In addition, chitosan gallate effectively inhibited the generation of intracellular reactive oxygen species (ROS), and also suppressed lipid peroxidation in RAW264.7 macrophage cells. Chitosan gallate also exhibited the protection effect on genomic DNA damage by induced hydroxyl radical, and up-regulated the protein expression of antioxidant enzymes including superoxide dismutase-1 and glutathione reductase under H2O2-mediated oxidative stress in RAW264.7 macrophage cells. These results indicate that chitosan gallate might be potential antioxidant biomaterials. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3070 / 3073
页数：4
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