Rituximab for the treatment of glomerulonephritis in hepatitis C associated cryoglobulinaemia

被引：0
作者：
Korte, M. R. [1 ]
van Heerde, M. J. [2 ]
de Man, R. A. [2 ]
Betjes, M. H. G. [1 ]
机构：
[1] Erasmus MC, Dept Nephrol, NL-3015 GD Rotterdam, Netherlands
[2] Erasmus MC, Dept Gastroenterol & Hepatol, NL-3015 GD Rotterdam, Netherlands
来源：
NETHERLANDS JOURNAL OF MEDICINE | 2008年 / 66卷 / 01期
关键词：
cryoglobulinaemia; glomerulonephritis; hepatitis C; liver transplantation; rituximab;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Mixed-type cryoglobulins are strongly associated with hepatitis C virus (HCV) infection and may lead to vasculitis with renal involvement. The treatment of this condition is antiviral therapy for HCV, but this may be ineffective or not tolerated because of side effects. Alternative strategies such as immunosuppressive drugs and plasmapheresis are of limited use, especially in patients after liver transplantation (LTx). We describe an LTx patient with cryoglobulinaemia-associated glomerulonephritis, who was treated successfully with the B cell depleting monoclonal antibody rituximab.
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页码：27 / 30
页数：4
相关论文
共 27 条
[1]   A ROLE FOR HEPATITIS-C VIRUS-INFECTION IN TYPE-II CRYOGLOBULINEMIA [J].
AGNELLO, V ;
CHUNG, RT ;
KAPLAN, LM .
NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (21) :1490-1495
[2]   Treatment of refractory antibody mediated autoimmune disorders with an anti-CD20 monoclonal antibody (rituximab) [J].
Arzoo, K ;
Sadeghi, S ;
Liebman, HA .
ANNALS OF THE RHEUMATIC DISEASES, 2002, 61 (10) :922-924
[3]   Rituximab therapy for mixed cryoglobulinemia in seven renal transplant patients [J].
Basse, G. ;
Ribes, D. ;
Kamar, N. ;
Mehrenberger, M. ;
Sallusto, F. ;
Esposito, L. ;
Guitard, J. ;
Lavayssiere, L. ;
Oksman, F. ;
Durand, D. ;
Rostaing, L. .
TRANSPLANTATION PROCEEDINGS, 2006, 38 (07) :2308-2310
[4]   The clinical and morphologic spectrum of renal cryoglobulinemia [J].
Beddhu, S ;
Bastacky, S ;
Johnson, JP .
MEDICINE, 2002, 81 (05) :398-409
[5]   Rituximab induces regression of hepatitis C virus-related membranoproliferative glomerulonephritis in a renal allograft [J].
Bestard, Oriol ;
Cruzado, Josep M. ;
Ercilla, Guadalupe ;
Goma-i-Freixanet, Montse ;
Torras, Joan ;
Seron, Daniel ;
Rama, Ines ;
Ibernon, Meritxell ;
Vinas, Odette ;
Carrera, Marta ;
Grinyo, Josep M. .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 (08) :2320-2324
[6]   Treatment for glomerulonephritis in HCV-associated mixed cryoglobulinaemia -: anti-viral therapy vs rituximab [J].
Bruchfeld, A ;
Saadoun, D ;
Cacoub, P .
RHEUMATOLOGY, 2006, 45 (06) :783-784
[7]   Cryoglobulinemia vasculitis [J].
Cacoub, P ;
Costedoat-Chalumeau, N ;
Lidove, O ;
Alric, L .
CURRENT OPINION IN RHEUMATOLOGY, 2002, 14 (01) :29-35
[8]  
Coiffier B, 1998, BLOOD, V92, P1927
[9]  
Davis C L, 1995, Liver Transpl Surg, V1, P166, DOI 10.1002/lt.500010306
[10]  
De Vita S, 2000, ARTHRITIS RHEUM, V43, P94, DOI 10.1002/1529-0131(200001)43:1<94::AID-ANR12>3.0.CO
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