Change in standardized uptake values in delayed 18F-FDG positron emission tomography images in hepatocellular carcinoma

被引:5
作者
Oksuzoglu, Kevser [1 ]
Ones, Tunc [1 ]
Ozguven, Salih [1 ]
Inanir, Sabahat [1 ]
Turoglu, Halil Turgut [1 ]
Bozkurtlar, Emine [2 ]
Celikel, Cigdem Ataizi [2 ]
Erdil, Tanju Yusuf [1 ]
机构
[1] Marmara Univ, Pendik Res & Training Hosp, Dept Nucl Med, Kayasultan Sokak,Aydogan Sitesi,58 A Blok,Daire 5, TR-34742 Istanbul, Turkey
[2] Marmara Univ, Pend Res & Training Hosp, Dept Pathol, Istanbul, Turkey
关键词
F-18-FDG positron emission tomography; delayed images; dual-phase imaging; hepatocellular carcinoma; standardized uptake value; DUAL-TIME-POINT; GLUCOSE-METABOLISM; PET; DIAGNOSIS; TUMORS; FLUORINE-18-FLUORODEOXYGLUCOSE; INJECTION; CANCER;
D O I
10.1097/MD.0000000000012817
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Delayed 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography (PET) imaging has been associated with improved diagnostic yield in several malignancies; however, data on the use of delayed imaging in patients with hepatocellular carcinoma (HCC) is scarce. This study aimed to examine tumoral and background standardized uptake value (SUV) alterations in dual-phase 18F-FDG PET/computed tomography (CT) imaging. Fifty-two HCC cases underwent dual-time-point 18F-FDG PET/CT examination where early and delayed images were obtained. The maximum and mean SUVs (SUVmax and SUVmean) of the tumor were determined for both time points. Similarly, the average SUVmean were also determined for background (liver, soft tissue, and spleen). Changes in tumoral and background SUV between early and delayed images were examined. The mean age was 62.0 +/- 12.9 years (range, 20-88 years) and the majority of the patients were men (86.5%). Tumor SUVs, both tumor SUVmean and tumor SUVmax, significantly increased at delayed images when compared to early images. In contrast, the average SUVmean for the liver, soft tissue, and spleen significantly decreased at delayed images. A significant increase in tumor SUV in delayed images in contrast to a significant decrease in background SUVs suggests that delayed images in HCC may contribute to diagnostic performance through a potential increase in the contrast between the tumor and background. However, further studies with larger sample sizes including patients with benign lesions and different grades of the disease are warranted to better elucidate the diagnostic contribution as well as the association of delayed imaging values with prognosis.
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页数:6
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共 29 条
[1]  
Beaulieu S, 2003, J NUCL MED, V44, P1044
[2]   Management of Hepatocellular Carcinoma: An Update [J].
Bruix, Jordi ;
Sherman, Morris .
HEPATOLOGY, 2011, 53 (03) :1020-1022
[3]   Dual-phase 18F-FDG PET in the diagnosis of pulmonary nodules with an initial standard uptake value less than 2.5 [J].
Chen, Chao-Jung ;
Lee, Bi-Fang ;
Yao, Wei-Jen ;
Cheng, Lili ;
Wu, Pei-Shan ;
Chu, Ching Lin ;
Chiu, Nan-Tsing .
AMERICAN JOURNAL OF ROENTGENOLOGY, 2008, 191 (02) :475-479
[4]   When should we recommend use of dual time-point and delayed time-point imaging techniques in FDG PET? [J].
Cheng, Gang ;
Torigian, Drew A. ;
Zhuang, Hongming ;
Alavi, Abass .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2013, 40 (05) :779-787
[5]   18F-FDG PET CT as a prognostic factor in hepatocellular carcinoma [J].
Cho, Eunae ;
Jun, Chung-Hwan ;
Kim, Ban-Seok ;
Son, Dong-Jun ;
Choi, Won-Suk ;
Choi, Sung-Kyu .
TURKISH JOURNAL OF GASTROENTEROLOGY, 2015, 26 (04) :344-350
[6]   Limitations of dual time point PET in the assessment of lung nodules with low FDG avidity [J].
Cloran, Francis J. ;
Banks, Kevin P. ;
Song, Won S. ;
Kim, Young ;
Bradley, Yong C. .
LUNG CANCER, 2010, 68 (01) :66-71
[7]   New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1) [J].
Eisenhauer, E. A. ;
Therasse, P. ;
Bogaerts, J. ;
Schwartz, L. H. ;
Sargent, D. ;
Ford, R. ;
Dancey, J. ;
Arbuck, S. ;
Gwyther, S. ;
Mooney, M. ;
Rubinstein, L. ;
Shankar, L. ;
Dodd, L. ;
Kaplan, R. ;
Lacombe, D. ;
Verweij, J. .
EUROPEAN JOURNAL OF CANCER, 2009, 45 (02) :228-247
[8]   Hepatocellular carcinoma [J].
Forner, Alejandro ;
Llovet, Josep M. ;
Bruix, Jordi .
LANCET, 2012, 379 (9822) :1245-1255
[9]  
Higashi T, 2002, J NUCL MED, V43, P173
[10]   Dual-tracer PET/CT imaging in evaluation of metastatic hepatocellular carcinoma [J].
Ho, Chi-Lai ;
Chen, Sirong ;
Yeung, David W. C. ;
Cheng, Thomas K. C. .
JOURNAL OF NUCLEAR MEDICINE, 2007, 48 (06) :902-909