Direct Synthesis of Sulfonylated Spiro[indole-3,3′-pyrrolidines] by Silver-Mediated Sulfonylation of Acrylamides Coupled with Indole Dearomatization

被引：32

作者：

Dong, Wei ^{[1
]}

Qi, Lin ^{[1
]}

Song, Jin-Yan ^{[1
]}

Chen, Jia-Min ^{[1
]}

Guo, Jia-Xin ^{[1
]}

Shen, Song ^{[1
]}

Li, Li-Jun ^{[1
]}

Li, Wei ^{[1
,2
]}

Wang, Li-Jing ^{[1
,2
]}

机构：

[1] Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Peoples R China

[2] Hebei Univ, Key Lab Med Chem & Mol Diag, Minist Educ, Key Lab Chem Biol Hebei Prov, Baoding 071002, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 05期

基金：

中国国家自然科学基金;

关键词：

QUINOLINE N-OXIDES; SULFUR-DIOXIDE; CYCLIZATION; 1,6-ENYNES; INSERTION; ALKENES; ACCESS; SPIROCYCLIZATION; OXYSULFONYLATION; SCAFFOLDS;

D O I：

10.1021/acs.orglett.0c00158

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A dearomative tandem spiro-cyclization reaction of N-[(1H-indol-3-yl)methyl]methacrylamide derivatives with sulfinate sodium in the presence of AgNO3 and K2CO3 is reported, which produced sulfonylated spiro[indole-3,3'-pyrrolidines] in medium to excellent yields. The characteristics of this transformation contain good functional group tolerance and ease of operation.

引用

页码：1830 / 1835

页数：6

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