Innate immune cell populations function as initiators and effectors in Th2 cytokine responses

被引：120

作者：

Saenz, Steven A. ^{[1
,2
]}

Noti, Mario ^{[1
,2
]}

Artis, David ^{[1
,2
]}

机构：

[1] Univ Penn, Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA

来源：

TRENDS IN IMMUNOLOGY | 2010年 / 31卷 / 11期

关键词：

HELPER T-CELLS; ST2; PROTEIN; STEM-CELLS; EXPRESSION; ASTHMA; IL-33; GENE; IDENTIFICATION; RECOGNITION; INDUCER;

D O I：

10.1016/j.it.2010.09.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The recent identification of previously unrecognized innate cell populations, termed natural helper cells (NHCs), multi-potent progenitor type 2 (MPPtype2) cells, nuocytes and innate type 2 helper (Ih2) cells has provided new insights into our understanding of the cellular mechanisms that lead to the development of CD4(+) Th2 cell-dependent immunity and/or inflammation at mucosa! sites In this review, we focus on the functional significance, similarities, and differences between NHCs, MPPtype2 cells, nuocytes and Ih2 cells All four cell populations are activated by interleukin (IL)-25 and/or IL-33 and are capable of promoting Th2 cytokine responses Collectively, the identification of these cell populations might illuminate ancient evolutionary conserved pathways that are involved in the development of Th2 cytokine responses, and could be of benefit in the development of therapeutic approaches that target helminth infections and allergic diseases

引用

页码：407 / 413

页数：7

共 53 条

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