TMEM16A Protein: A New Identity for Ca2+-Dependent Cl- Channels

被引：90
作者：
Ferrera, Loretta [1 ]
Caputo, Antonella [1 ]
Galietta, Luis J. V. [1 ]
机构：
[1] Ist Giannina Gaslini, Mol Genet Lab, I-16148 Genoa, Italy
来源：
PHYSIOLOGY | 2010年 / 25卷 / 06期
关键词：
ACTIVATED CHLORIDE CHANNEL; SMOOTH-MUSCLE; INTERSTITIAL-CELLS; TRANSMEMBRANE PROTEIN; APICAL MEMBRANE; CALCIUM; EXPRESSION; SECRETION; CURRENTS; GENE;
D O I：
10.1152/physiol.00030.2010
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Ca+-dependent Cl- channels (CaCCs) play a variety of physiological roles in different organs and tissues, including transepithelial Cl- secretion, smooth muscle contraction, regulation of neuronal excitability, and transduction of sensory stimuli. The recent identification of TMEM16A protein as an important component of CaCCs should allow a better understanding of their physiological role, structure-function relationship, and regulatory mechanisms.
引用
收藏
页码：357 / 363
页数：7
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