TMEM16A Protein: A New Identity for Ca2+-Dependent Cl- Channels

被引：90

作者：

Ferrera, Loretta ^{[1
]}

Caputo, Antonella ^{[1
]}

Galietta, Luis J. V. ^{[1
]}

机构：

[1] Ist Giannina Gaslini, Mol Genet Lab, I-16148 Genoa, Italy

来源：

PHYSIOLOGY | 2010年 / 25卷 / 06期

关键词：

ACTIVATED CHLORIDE CHANNEL; SMOOTH-MUSCLE; INTERSTITIAL-CELLS; TRANSMEMBRANE PROTEIN; APICAL MEMBRANE; CALCIUM; EXPRESSION; SECRETION; CURRENTS; GENE;

D O I：

10.1152/physiol.00030.2010

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Ca+-dependent Cl- channels (CaCCs) play a variety of physiological roles in different organs and tissues, including transepithelial Cl- secretion, smooth muscle contraction, regulation of neuronal excitability, and transduction of sensory stimuli. The recent identification of TMEM16A protein as an important component of CaCCs should allow a better understanding of their physiological role, structure-function relationship, and regulatory mechanisms.

引用

页码：357 / 363

页数：7

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