TMEM16A Protein: A New Identity for Ca2+-Dependent Cl- Channels

被引：90
|
作者：
Ferrera, Loretta [1 ]
Caputo, Antonella [1 ]
Galietta, Luis J. V. [1 ]
机构：
[1] Ist Giannina Gaslini, Mol Genet Lab, I-16148 Genoa, Italy
来源：
PHYSIOLOGY | 2010年 / 25卷 / 06期
关键词：
ACTIVATED CHLORIDE CHANNEL; SMOOTH-MUSCLE; INTERSTITIAL-CELLS; TRANSMEMBRANE PROTEIN; APICAL MEMBRANE; CALCIUM; EXPRESSION; SECRETION; CURRENTS; GENE;
D O I：
10.1152/physiol.00030.2010
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Ca+-dependent Cl- channels (CaCCs) play a variety of physiological roles in different organs and tissues, including transepithelial Cl- secretion, smooth muscle contraction, regulation of neuronal excitability, and transduction of sensory stimuli. The recent identification of TMEM16A protein as an important component of CaCCs should allow a better understanding of their physiological role, structure-function relationship, and regulatory mechanisms.
引用
收藏
页码：357 / 363
页数：7
相关论文
共 50 条
  • [21] Ca2+-activated Cl- channels (TMEM16A) underlie spontaneous electrical activity in isolated mouse corpus cavernosum smooth muscle cells
    Lim, Xin Rui
    Drumm, Bernard T.
    Sergeant, Gerard P.
    Hollywood, Mark A.
    Thornbury, Keith D.
    PHYSIOLOGICAL REPORTS, 2022, 10 (22):
  • [22] Tmem16A Encodes the Ca2+-activated Cl- Channel in Mouse Submandibular Salivary Gland Acinar Cells
    Romanenko, Victor G.
    Catalan, Marcelo A.
    Brown, David A.
    Putzier, Ilva
    Hartzell, H. Criss
    Marmorstein, Alan D.
    Gonzalez-Begne, Mireya
    Rock, Jason R.
    Harfe, Brian D.
    Melvin, James E.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (17) : 12990 - 13001
  • [23] Activation of TMEM16A Ca2+-activated Cl- channels by ROCK1/moesin promotes breast cancer metastasis
    Luo, Shuya
    Wang, Hui
    Bai, Lichuan
    Chen, Yiwen
    Chen, Si
    Gao, Kuan
    Wang, Huijie
    Wu, Shuwei
    Song, Hanbin
    Ma, Ke
    Liu, Mei
    Yao, Fan
    Fang, Yue
    Xiao, Qinghuan
    JOURNAL OF ADVANCED RESEARCH, 2021, 33 : 253 - 264
  • [24] The multiple expression of Ca2+-activated Cl- channels via homo- and hetero-dimer formation of TMEM16A splicing variants in murine portal vein
    Ohshiro, Junya
    Yamamura, Hisao
    Saeki, Takanori
    Suzuki, Yoshiaki
    Imaizumi, Yuji
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 443 (02) : 518 - 523
  • [25] The Ca2+-activated Cl- channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis
    Qu, Zhiqiang
    Yao, Weicheng
    Yao, Ruyong
    Liu, Xiangping
    Yu, Kuai
    Hartzell, Criss
    CANCER MEDICINE, 2014, 3 (03): : 453 - 461
  • [26] Anoctamin 1/TMEM16A controls intestinal Cl- secretion induced by carbachol and cholera toxin
    Lee, Byeongjun
    Hong, Gyu-Sang
    Lee, Sung Hoon
    Kim, Hyungsup
    Kim, Ajung
    Hwang, Eun Mi
    Kim, Jiyoon
    Lee, Min Goo
    Yang, Jin-Young
    Kweon, Mi-Na
    Tse, Chung-Ming
    Mark, Donowitz
    Oh, Uhtaek
    EXPERIMENTAL AND MOLECULAR MEDICINE, 2019, 51 (8): : 1 - 14
  • [27] Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels
    Hartzell, H. Criss
    Yu, Kuai
    Xiao, Qinhuan
    Chien, Li-Ting
    Qu, Zhiqiang
    JOURNAL OF PHYSIOLOGY-LONDON, 2009, 587 (10): : 2127 - 2139
  • [28] The Ca2+-activated Cl- channel ANO1/TMEM16A regulates primary ciliogenesis
    Ruppersburg, Chelsey Chandler
    Hartzell, H. Criss
    MOLECULAR BIOLOGY OF THE CELL, 2014, 25 (11) : 1793 - 1807
  • [29] Calmodulin regulation of TMEM16A and 16B Ca2+-activated chloride channels
    Yang, Tingting
    Colecraft, Henry M.
    CHANNELS, 2016, 10 (01) : 38 - 44
  • [30] Mechanosensitive Cl- secretion in biliary epithelium mediated through TMEM16A
    Dutta, Amal K.
    Woo, Kangmee
    Khimji, Al-karim
    Kresge, Charles
    Feranchak, Andrew P.
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2013, 304 (01): : G87 - G98
12345