The emerging roles of KPNA2 in cancer

被引：79
作者：
Han, Yang [1 ,2 ]
Wang, Xin [1 ,2 ,3 ,4 ]
机构：
[1] Shandong Univ, Shandong Prov Hosp, Dept Hematol, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China
[2] Shandong Univ, Sch Med, Jinan 250012, Shandong, Peoples R China
[3] Shandong Prov Engn Res Ctr Lymphoma, Jinan 250021, Shandong, Peoples R China
[4] Key Lab Kidney Regenerat Shandong Prov, Jinan 250021, Shandong, Peoples R China
来源：
LIFE SCIENCES | 2020年 / 241卷
关键词：
KPNA2; Tumor progress; Nucleocytoplasmic transport; Diagnostic biomarker; SQUAMOUS-CELL CARCINOMA; QUANTITATIVE PROTEOMICS REVEALS; EPITHELIAL OVARIAN-CANCER; KARYOPHERIN-ALPHA; POOR-PROGNOSIS; BREAST-CANCER; NUCLEOCYTOPLASMIC TRANSPORT; NUCLEAR TRANSLOCATION; UROTHELIAL CARCINOMA; SUBUNIT ALPHA-2;
D O I：
10.1016/j.lfs.2019.117140
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Karyopherin alpha 2 (KPNA2, also known as importin alpha-1), a member of the nuclear transporter family, is involved in the nucleocytoplasmic transport pathway of a variety of tumor-associated proteins. Recent studies have found that KPNA2 is overexpressed in various cancers, which is associated with poor prognosis. In addition, it has been shown to promote tumor formation and progression by participating in cell differentiation, proliferation, apoptosis, immune response, and viral infection. It is indicated that KPNA2 also plays an important role in the diagnosis, treatment and prognosis of tumors. Herein, we provide an overview of the function and mechanism of KPNA2 in cancer and the prospects in the diagnosis and treatment of cancer. In the future, KPNA2 provides new ideas for the early diagnosis of malignant tumors, the development of molecularly targeted drugs, and prognosis evaluation.
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页数：9
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