Monoclonal B Cell Lymphocytosis: Clinical and Population Perspectives

被引：5

作者：

Caporaso, Neil E. ^{[1
]}

Marti, Gerald E. ^{[2
]}

Landgren, Ola ^{[3
]}

Azzato, Elizabeth

Weinberg, J. Brice ^{[4
,5
]}

Goldin, Lynn

Shanafelt, Tait ^{[6
]}

机构：

[1] NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, EPS 7116, Bethesda, MD 20892 USA

[2] US FDA, Off Cellular Tissue & Gene Therapies, Ctr Biol Res & Evaluat, Bethesda, MD 20892 USA

[3] Ctr Canc Res, Med Oncol Branch, Bethesda, MD 20892 USA

[4] Duke Univ, Durham, NC 27705 USA

[5] VA Med Ctr, Durham, NC 27705 USA

[6] Mayo Clin, Dept Med, Rochester, MN 55905 USA

来源：

CYTOMETRY PART B-CLINICAL CYTOMETRY | 2010年 / 78B卷

关键词：

chronic lymphocytic leukemia; monoclonal B cell lymphocytosis; population; lymphocytosis; DIAGNOSTIC-CRITERIA; NATURAL-HISTORY; SUSCEPTIBILITY LOCI; FLOW-CYTOMETRY; LEUKEMIA; CLASSIFICATION; FAMILIES; RISK; CLL; PREVALENCE;

D O I：

10.1002/cyto.b.20555

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Monoclonal B Cell Lymphocytosis (MBL) refers to clones of CLL-like cells that exhibit CLL characteristics that fall short of the numbers required for CLL diagnosis. Data from large CLL kindreds document increased prevalence of MBL suggesting a genetic contribution to its etiology. The molecular features that favor progression of MBL to CLL are poorly understood but an elevated B-cell count is a risk factor for progression. An important consideration when evaluating volunteers from CLL families who are willing to donate bone marrow is that MBL be ruled out since the MBL donor clone could result in a second CLL in the recipient. Further studies of MBL are needed to identify the molecular features and how they evolve during progression. Published 2010 Wiley-Liss, Inc.(dagger)

引用

页码：S115 / S119

页数：5

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