Persistent shedding of West Nile virus in urine of experimentally infected hamsters

被引：82
作者：
Tonry, JH
Xiao, SY
Siirin, MA
Chen, HL
Da Rosa, APAT
Tesh, RB [1 ]
机构：
[1] Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77550 USA
[2] Univ Texas, Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77550 USA
来源：
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2005年 / 72卷 / 03期
关键词：
D O I：
10.4269/ajtmh.2005.72.320
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Adult hamsters that survived experimental West Nile virus (WNV) infection developed persistent viruria. Infectious WNV could be cultured from their urine for up to 52 days. Immunohistochemical examination of kidneys of viruric animals showed foci of WNV antigen in renal tubular epithelial and vascular endothelial cells. These findings are compatible with virus replication and persistent infection of renal epithelial cells. The potential clinical and virologic significance of these findings as well as their possible epidermologic importance are discussed.
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页码：320 / 324
页数：5
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