Normal tissue tolerance to external beam radiation therapy: Liver

被引：24

作者：

De Bari, B. ^{[1
,2
]}

Pointreau, Y. ^{[3
]}

Rio, E.

Mirabel, X. ^{[4
,5
]}

Mornex, F. ^{[1
,2
]}

机构：

[1] Univ Lyon 1, Ctr Hosp Lyon Sud, Dept Radiotherapie Oncol, F-69310 Pierre Benite, France

[2] EA3738, F-69310 Pierre Benite, France

[3] CHU Tours, Ctr Reg Univ Cancerol Henry S Kaplan, Serv Radiotherapie, Hop Bretonneau, F-37000 Tours, France

[4] Ctr Reg Lutte Canc Nantes Atlantique, Serv Radiotherapie, F-44805 St Herblain, France

[5] Ctr Oscar Lambret, F-59000 Lille, France

来源：

CANCER RADIOTHERAPIE | 2010年 / 14卷 / 4-5期

关键词：

Liver; Organ at risk; Tolerability; Ionizing radiation; Radiotherapy; NTCP; Stereotactic; STEREOTACTIC BODY RADIOTHERAPY; PHASE-I; IRRADIATION; METASTASES; SBRT; PALLIATION; TOXICITY; TRIAL;

D O I：

10.1016/j.canrad.2010.02.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The liver is a large abdominal organ in the right hypondrium. Because of its anatomical situation, it is near many abdominal PTVs as well as some lower thoracic PVTs. The liver could also be at the same time the target (for irradiation of liver metastases or primary liver tumours) and organ at risk (OAR). Radiation-induced liver disease (RILD) is radiobiologically the normal tissue complication probability (NTCP), i.e., the clinical event limiting the total dose that could be delivered. This review describes radiobiological criteria justifying the NTCP data, and recommendations for conformal 3D radiotherapy and stereotactic liver irradiation. (C) 2010 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.

引用

页码：344 / 349

页数：6

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