Whole-genome scanning for the litter size trait associated genes and SNPs under selection in dairy goat (Capra hircus)

被引：104

作者：

Lai, Fang-Nong ^{[1
]}

Zhai, Hong-Li ^{[2
]}

Cheng, Ming ^{[3
]}

Ma, Jun-Yu ^{[1
]}

Cheng, Shun-Feng ^{[1
]}

Ge, Wei ^{[1
]}

Zhang, Guo-Liang ^{[1
]}

Wang, Jun-Jie ^{[1
]}

Zhang, Rui-Qian ^{[1
]}

Wang, Xue ^{[4
]}

Min, Ling-Jiang ^{[1
]}

Song, Jiu-Zhou ^{[5
]}

Shen, Wei ^{[1
]}

机构：

[1] Qingdao Agr Univ, Coll Anim Sci & Technol, Key Lab Anim Reprod & Germplasm Enhancement Univ, Qingdao 266109, Peoples R China

[2] Shandong Int Biotechnol Pk, Yantai 264670, Peoples R China

[3] Qingdao Res Inst Husb & Vet, Qingdao 266300, Peoples R China

[4] Qingdao Agr Univ, Coll Life Sci, Qingdao 266109, Peoples R China

[5] Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

关键词：

INCREASED OVULATION RATE; GRANULOSA-CELLS; IDENTIFICATION; EXPRESSION; MUTATIONS; BMP15; MICE;

D O I：

10.1038/srep38096

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dairy goats are one of the most utilized domesticated animals in China. Here, we selected extreme populations based on differential fecundity in two Laoshan dairy goat populations. Utilizing deep sequencing we have generated 68.7 and 57.8 giga base of sequencing data, and identified 12,458,711 and 12,423,128 SNPs in the low fecundity and high fecundity groups, respectively. Following selective sweep analyses, a number of loci and candidate genes in the two populations were scanned independently. The reproduction related genes CCNB2, AR, ADCY1, DNMT3B, SMAD2, AMHR2, ERBB2, FGFR1, MAP3K12 and THEM4 were specifically selected in the high fecundity group whereas KDM6A, TENM1, SWI5 and CYM were specifically selected in the low fecundity group. A sub-set of genes including SYCP2, SOX5 and POU3F4 were localized both in the high and low fecundity selection windows, suggesting that these particular genes experienced strong selection with lower genetic diversity. From the genome data, the rare nonsense mutations may not contribute to fecundity, whereas nonsynonymous SNPs likely play a predominant role. The nonsynonymous exonic SNPs in SETDB2 and CDH26 which were co-localized in the selected region may take part in fecundity traits. These observations bring us a new insights into the genetic variation influencing fecundity traits within dairy goats.

引用

页数：12

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