A dual role for genetically modified lymphocytes in cancer immunotherapy

被引：21

作者：

Russo, Vincenzo ^{[1
]}

Bondanza, Attilio ^{[2
,3
]}

Ciceri, Fabio ^{[3
]}

Bregni, Marco ^{[1
,3
]}

Bordignon, Claudio ^{[4
,5
]}

Traversari, Catia ^{[5
]}

Bonini, Chiara ^{[2
,3
]}

机构：

[1] Ist Sci San Raffaele, Canc Gene Therapy Unit, I-20132 Milan, Italy

[2] Ist Sci San Raffaele, Expt Hematol Unit, Canc Immunotherapy & Gene Therapy Program, I-20132 Milan, Italy

[3] Ist Sci San Raffaele, Bone Marrow Transplantat Unit, I-20132 Milan, Italy

[4] Univ Vita Salute San Raffaele, Milan, Italy

[5] Molmed SpA, Milan, Italy

来源：

TRENDS IN MOLECULAR MEDICINE | 2012年 / 18卷 / 04期

关键词：

SUICIDE GENE-THERAPY; T-CELL-RECEPTORS; VERSUS-HOST-DISEASE; PHASE-I; ANTITUMOR-ACTIVITY; DONOR LYMPHOCYTES; DENDRITIC CELLS; TUMOR-ANTIGENS; IMMUNE ESCAPE; CD8(+);

D O I：

10.1016/j.molmed.2011.12.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

T cells as the ultimate effectors of adaptive immune responses are currently used to treat patients affected by infectious diseases and certain tumors. Recently, T cells have been manipulated ex vivo with viral vectors coding for chimeric antigen receptors, exogenous T cell receptors, or 'suicide' genes to potentiate their efficacy and minimize possible side effects. However, the introduction of exogenous genes into T lymphocytes, particularly bacterial or viral transgene products, has occasionally produced immune-mediated elimination of transduced lymphocytes. This immune effect has recently been exploited in a trial of active immunotherapy in melanoma patients. In this opinion article, we discuss the therapeutic possibilities presented by the dual aspects of genetically modified lymphocytes used to treat cancer patients.

引用

页码：193 / 200

页数：8

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