Detecting Pleiotropy and Epistasis Using Variance Components Linkage Analysis in jPAP

被引：5

作者：

Hasstedt, Sandra J. ^{[1
]}

Thomas, Alun ^{[2
]}

机构：

[1] Univ Utah, Dept Human Genet, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Internal Med, Div Genet Epidemiol, Salt Lake City, UT 84112 USA

来源：

HUMAN HEREDITY | 2011年 / 72卷 / 04期

关键词：

jPAP; Epistasis; Pleiotropy; Variance components linkage analysis; Quantitative trait loci; PEDIGREES; GENOTYPES; CANCER;

D O I：

10.1159/000331690

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

jPAP (Java Pedigree Analysis Package) performs variance components linkage analysis of either quantitative or discrete traits. Multivariate linkage analysis of two or more traits (all quantitative, all discrete, or any combination) allows the inference of pleiotropy between the traits. The inclusion of multiple quantitative trait loci in linkage analysis allows the inference of epistasis between loci. A user-friendly graphical user interface facilitates the usage of jPAP. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：258 / 263

页数：6

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