Diffuse intrinsic pontine gliomas: A systematic update on clinical trials and biology

被引：162

作者：

Jansen, M. H. A. ^{[1
,3
]}

van Vuurden, D. G. ^{[1
,3
]}

Vandertop, W. P. ^{[2
,3
]}

Kaspers, G. J. L. ^{[1
,3
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Dept Pediat, Div Pediat Oncol Hematol, NL-1007 MB Amsterdam, Netherlands

[2] Vrije Univ Amsterdam Med Ctr, Neurosurg Ctr Amsterdam, NL-1007 MB Amsterdam, Netherlands

[3] Vrije Univ Amsterdam Med Ctr, Canc Ctr Amsterdam, Neurooncol Res Grp, NL-1007 MB Amsterdam, Netherlands

来源：

CANCER TREATMENT REVIEWS | 2012年 / 38卷 / 01期

关键词：

Brain stem; Molecular targeted therapy; Pontine tumors; Pontine glioma; Glioma; BRAIN-STEM GLIOMA; POSITRON EMISSION TOMOGRAPHY; PHASE-I TRIAL; ADJUVANT TEMOZOLOMIDE; STEREOTACTIC BIOPSY; BARRIER DISRUPTION; RADIATION-THERAPY; CHILDREN; RADIOTHERAPY; CHEMOTHERAPY;

D O I：

10.1016/j.ctrv.2011.06.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients with diffuse intrinsic pontine gliomas (DIPG) have a poor prognosis. Although DIPG constitute only 10-15% of all pediatric brain tumors, they are the main cause of death in this group. Despite 26 clinical trials in newly diagnosed DIPG in the past 5 years (including several targeted agents), there is no clear improvement in prognosis. However, knowledge on DIPG biology is increasing, mainly due to the (re)introduction of biopsies and autopsies, the possibility of gene expression profiling, and the development of in vivo models. Translation of this knowledge into clinical trials in combination with improved drug distribution methods may eventually lead to more effective treatment of this devastating disease. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：27 / 35

页数：9

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