Diffuse intrinsic pontine gliomas: A systematic update on clinical trials and biology

被引：162
作者：
Jansen, M. H. A. [1 ,3 ]
van Vuurden, D. G. [1 ,3 ]
Vandertop, W. P. [2 ,3 ]
Kaspers, G. J. L. [1 ,3 ]
机构：
[1] Vrije Univ Amsterdam Med Ctr, Dept Pediat, Div Pediat Oncol Hematol, NL-1007 MB Amsterdam, Netherlands
[2] Vrije Univ Amsterdam Med Ctr, Neurosurg Ctr Amsterdam, NL-1007 MB Amsterdam, Netherlands
[3] Vrije Univ Amsterdam Med Ctr, Canc Ctr Amsterdam, Neurooncol Res Grp, NL-1007 MB Amsterdam, Netherlands
来源：
CANCER TREATMENT REVIEWS | 2012年 / 38卷 / 01期
关键词：
Brain stem; Molecular targeted therapy; Pontine tumors; Pontine glioma; Glioma; BRAIN-STEM GLIOMA; POSITRON EMISSION TOMOGRAPHY; PHASE-I TRIAL; ADJUVANT TEMOZOLOMIDE; STEREOTACTIC BIOPSY; BARRIER DISRUPTION; RADIATION-THERAPY; CHILDREN; RADIOTHERAPY; CHEMOTHERAPY;
D O I：
10.1016/j.ctrv.2011.06.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Patients with diffuse intrinsic pontine gliomas (DIPG) have a poor prognosis. Although DIPG constitute only 10-15% of all pediatric brain tumors, they are the main cause of death in this group. Despite 26 clinical trials in newly diagnosed DIPG in the past 5 years (including several targeted agents), there is no clear improvement in prognosis. However, knowledge on DIPG biology is increasing, mainly due to the (re)introduction of biopsies and autopsies, the possibility of gene expression profiling, and the development of in vivo models. Translation of this knowledge into clinical trials in combination with improved drug distribution methods may eventually lead to more effective treatment of this devastating disease. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：27 / 35
页数：9
相关论文
共 63 条
[1]   Post mortem examinations in diffuse intrinsic pontine glioma: challenges and chances [J].
Angelini, Paola ;
Hawkins, Cynthia ;
Laperriere, Normand ;
Bouffet, Eric ;
Bartels, Ute .
JOURNAL OF NEURO-ONCOLOGY, 2011, 101 (01) :75-81
[2]   Concurrent carbogen and radiation therapy in children with high-risk brainstem gliomas [J].
Aquino-Parsons, C. ;
Hukin, J. ;
Green, A. .
PEDIATRIC BLOOD & CANCER, 2008, 50 (02) :397-399
[3]   Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas [J].
Barrow, Jennifer ;
Adamowicz-Brice, Martyna ;
Cartmill, Maria ;
MacArthur, Donald ;
Lowe, James ;
Robson, Keith ;
Brundler, Marie-Anne ;
Walker, David A. ;
Coyle, Beth ;
Grundy, Richard .
NEURO-ONCOLOGY, 2011, 13 (02) :212-222
[4]   Performance of immuno-positron emission tomography with zirconium-89-labeled chimeric monoclonal antibody U36 in the detection of lymph node metastases in head and neck cancer patients [J].
Börjesson, PKE ;
Jauw, YWS ;
Boellaard, R ;
de Bree, R ;
Comans, EFI ;
Roos, JC ;
Castelijns, JA ;
Vosjan, MJWD ;
Kummer, JA ;
Leemans, CR ;
Lammertsma, AA ;
van Dongen, GAMS .
CLINICAL CANCER RESEARCH, 2006, 12 (07) :2133-2140
[5]   Motexafin gadolinium and involved field radiation therapy for intrinsic pontine glioma of childhood: A Children's Oncology Group phase I study [J].
Bradley, Kristin A. ;
Pollack, Ian F. ;
Reid, Joel M. ;
Adamson, Peter C. ;
Ames, Matthew M. ;
Vezina, Gilbert ;
Blaney, Susan ;
Ivy, Percy ;
Zhou, Tianni ;
Krallo, Mark ;
Reaman, Gregory ;
Mehta, Minesh P. .
NEURO-ONCOLOGY, 2008, 10 (05) :752-758
[6]   Phase I Study of Vandetanib During and After Radiotherapy in Children With Diffuse Intrinsic Pontine Glioma [J].
Broniscer, Alberto ;
Baker, Justin N. ;
Tagen, Michael ;
Onar-Thomas, Arzu ;
Gilbertson, Richard J. ;
Davidoff, Andrew M. ;
Panandiker, Atmaram Pai ;
Leung, Wing ;
Chin, Thomas K. ;
Stewart, Clinton F. ;
Kocak, Mehmet ;
Rowland, Christopher ;
Merchant, Thomas E. ;
Kaste, Sue C. ;
Gajjar, Amar .
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (31) :4762-4768
[7]   Prospective Collection of Tissue Samples at Autopsy in Children With Diffuse Intrinsic Pontine Glioma [J].
Broniscer, Alberto ;
Baker, Justin N. ;
Baker, Suzanne J. ;
Chi, Susan N. ;
Geyer, J. Russell ;
Morris, E. Brannon ;
Gajjar, Amar .
CANCER, 2010, 116 (19) :4632-4637
[8]  
Caretti V, 2010, BRAIN PATHOL
[9]   PARP and Cancer - If It's Broke, Don't Fix It. [J].
Carey, Lisa A. ;
Sharpless, Norman E. .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (03) :277-279
[10]  
Cartmill M, 1999, CHILD NERV SYST, V15, P235
1234567