Deconvoluting the context-dependent role for autophagy in cancer

被引：1435

作者：

White, Eileen ^{[1
,2
,3
]}

机构：

[1] Canc Inst New Jersey, New Brunswick, NJ 08903 USA

[2] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA

[3] Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 06期

基金：

美国国家卫生研究院;

关键词：

TUMOR-SUPPRESSOR GENE; RENAL-CELL CARCINOMA; TARGETING AUTOPHAGY; MITOCHONDRIAL METABOLISM; OXIDATIVE STRESS; P62; TUMORIGENESIS; DEGRADATION; NRF2; INHIBITION;

D O I：

10.1038/nrc3262

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Autophagy (also known as macroautophagy) captures intracellular components in autophagosomes and delivers them to lysosomes, where they are degraded and recycled. Autophagy can have two functions in cancer. It can be tumour suppressive through the elimination of oncogenic protein substrates, toxic unfolded proteins and damaged organelles. Alternatively, it can be tumour promoting in established cancers through autophagy-mediated intracellular recycling that provides substrates for metabolism and that maintains the functional pool of mitochondria. Therefore, defining the context-specific role for autophagy in cancer and the mechanisms involved will be important to guide autophagy-based therapeutic intervention.

引用

收藏

页码：401 / 410

页数：10

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