Cerebral infarction associated with moyamoya disease: histogram-based quantitative analysis of diffusion tensor imaging - a preliminary study

被引:12
作者
Mori, Nobuyuki [1 ]
Miki, Yukio [1 ]
Fushimi, Yasutaka [1 ]
Kikuta, Ken-ichiro [2 ]
Urayama, Shin-ichi [3 ]
Okada, Tsutomu [1 ]
Fukuyama, Hidenao [3 ]
Hashimoto, Nobuo [2 ]
Togashi, Kaori [1 ]
机构
[1] Kyoto Univ, Grad Sch Med, Dept Diagnost Imaging & Nucl Med, Sakyo Ku, Kyoto 6068507, Japan
[2] Kyoto Univ, Grad Sch Med, Dept Neurosurg, Sakyo Ku, Kyoto 6068507, Japan
[3] Kyoto Univ, Grad Sch Med, Human Brain Res Ctr, Sakyo Ku, Kyoto 6068507, Japan
关键词
moyamoya disease; diffusion tensor imaging; whole-brain histogram analysis;
D O I
10.1016/j.mri.2008.01.036
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Moyamoya disease (MMD) is a rare disorder of unknown etiology in which terminal portions of the internal carotid arteries become steno-occlusive, with fine collateral "moyarnoya vessels" formed secondarily, resulting in serial ischemic strokes throughout its clinical course. Whole-brain histogram (WBH) of diffusion tensor imaging (WBH-DTI) is an analytical tool whose feasibility has been ascertained in various pathologies. To elucidate whether WBH-DTI could detect any difference between ischemic MMD and normal controls, we examined 27 consecutive MMD patients without hemorrhage and 48 normal controls in this prospective study using a 3.0-T magnetic resonance scanner. WBHs of fractional anisotropy (FA) (WBH-FA) and mean diffusivity (MD) (WBH-MD) were compared among three groups: Group 1, MMD patients with infarct (n=15); Group 2, MMD patients without infarct (n=12); and Group 3, normal controls (n=48). Group 1 showed significantly higher peak height and significantly lower mean value on WBH-FA, as well as significantly lower peak height and significantly higher mean value on WBH-MD, compared with Groups 2 and 3. No significant difference was seen in parameters at either WBH-FA or WBH-MD between Groups 2 and 3. These results might reflect the pathological severity of each group, and WBH-DTI could feasibly detect differences between ischemic MMD with infarction and MMD without infarction and normal controls. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:835 / 840
页数:6
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