Antibiotic drug discovery

被引：104

作者：

Wohlleben, Wolfgang ^{[1
,2
]}

Mast, Yvonne ^{[1
,2
]}

Stegmann, Evi ^{[1
,2
]}

Ziemert, Nadine ^{[1
,2
]}

机构：

[1] Univ Tubingen, Microbiol Biotechnol, Interfac Inst Microbiol & Infect Med Tuebingen, Morgenstelle 28, Tubingen, Germany

[2] German Ctr Infect Res DZIF, Partner Site Tuebingen, Tubingen, Germany

来源：

MICROBIAL BIOTECHNOLOGY | 2016年 / 9卷 / 05期

关键词：

BIOSYNTHETIC GENE CLUSTERS; NATURAL-PRODUCTS; MASS-SPECTROMETRY; MOLECULAR NETWORKING; MICROBIAL METABOLITES; SECONDARY METABOLISM; IDENTIFICATION; STREPTOMYCES; ELUCIDATION; SALINISPORA;

D O I：

10.1111/1751-7915.12388

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Due to the threat posed by the increase of highly resistant pathogenic bacteria, there is an urgent need for new antibiotics; all the more so since in the last 20 years, the approval for new antibacterial agents had decreased. The field of natural product discovery has undergone a tremendous development over the past few years. This has been the consequence of several new and revolutionizing drug discovery and development techniques, which is initiating a 'New Age of Antibiotic Discovery'. In this review, we concentrate on the most significant discovery approaches during the last and present years and comment on the challenges facing the community in the coming years.

引用

页码：541 / 548

页数：8

共 57 条

[1] Elicitation of secondary metabolism in actinomycetes [J].