How harmful is contralateral testicular biopsy? An analysis of serial imaging studies and a prospective evaluation of surgical complications

被引:34
作者
Dieckmann, KP
Heinemann, V
Frey, U
Pichlmeier, U
机构
[1] Albertinen Krankenhaus, Urol Abt, D-22457 Hamburg, Germany
[2] Albertinen Krankenhaus, Rontgendiagnost Abt, D-22457 Hamburg, Germany
[3] Univ Hamburg, Krankenhaus Eppendorf, Zentrum Expt Med, Inst Med Biometrie & Epidemiol, D-2000 Hamburg, Germany
关键词
testicular biopsy; surgical complications; scrotal sonography; magnetic resonance imaging; testicular neoplasm;
D O I
10.1016/j.eururo.2005.06.008
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objective: Testicular biopsy has recently gained a role in early detection of testicular cancer. However, its use is still limited mainly because of the fear of untoward consequences. There is a paucity of data regarding unfavourable effects of testicular biopsy. Therefore, we systematically looked to the consequences of the procedure by using clinical observational methods and by modern imaging techniques, respectively. Patients, methods: 1874 patients with testicular cancer enrolled in a nation-wide contralateral biopsy study were prospectively analyzed in regard to surgical complications. Serial scrotal imaging was performed by scrotal sonography (7.5 Mhz) in 55 patients and by magnetic resonance tomography (1.5 Tesla machine, surface coil, contrast media) in 60 patients, respectively. Imaging examinations were done preoperatively and again at 1 week, 6 months, 12 months, and 18 months respectively. Imaging results were tabulated according to an abnormality score and analyzed by descriptive statistics. Results: 52 patients (2.78%; 95% confidence intervals 2.05-3.60) experienced surgical complications. Forty minor complications were managed conservatively. Twelve patients (0.64%) required repeat surgery; 1 testicle was ultimately lost following a sequence of unfortunate events. No pre-existing clinical parameter was associated with complications. One week after surgery, abnormalities were detected in 33% by sonography and in 45% by MRI, respectively. Importantly, the abnormalities resolved in 96% of the cases, as found in both of the imaging modalities in the serial scans. Conclusions: Testicular biopsy is associated with a low burden of clinically significant complications. However, scrotal imaging discloses intratesticular abnormalities in a high proportion of cases one week after the biopsy. These changes represent focal haematoma, oedema or circumscript injury to vascular supply. Most of these lesions resolve with time and are thus not significant, clinically. Evidently, testicular biopsy is a safe procedure provided the vascular anatomy of the testis is respected upon surgery. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:662 / 672
页数:11
相关论文
共 40 条
[1]   Magnetic resonance imaging and ultrasound evaluation of penile and testicular masses [J].
Andipa, E ;
Liberopoulos, K ;
Asvestis, C .
WORLD JOURNAL OF UROLOGY, 2004, 22 (05) :382-391
[2]   TESTICULAR BIOPSY AS AN OUTPATIENT PROCEDURE IN SCREENING FOR CARCINOMA-INSITU - COMPLICATIONS AND THE PATIENTS ACCEPTANCE [J].
BRUUN, E ;
FRIMODTMOLLER, C ;
GIWERCMAN, A ;
LENZ, S ;
SKAKKEBAEK, NE .
INTERNATIONAL JOURNAL OF ANDROLOGY, 1987, 10 (01) :199-202
[3]   REFINING BINOMIAL CONFIDENCE-INTERVALS [J].
CASELLA, G .
CANADIAN JOURNAL OF STATISTICS-REVUE CANADIENNE DE STATISTIQUE, 1986, 14 (02) :113-129
[4]   Test-based exact confidence intervals for the difference of two binomial proportions [J].
Chan, ISF ;
Zhang, ZX .
BIOMETRICS, 1999, 55 (04) :1202-1209
[5]   Testicular biopsy - Its value in male sterility [J].
Charny, CW .
JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1940, 115 :1429-1433
[6]   Stage II testicular seminoma: Patterns of recurrence and outcome of treatment [J].
Chung, PWM ;
Gospodarowicz, MK ;
Panzarella, T ;
Jewett, MAS ;
Sturgeon, JFG ;
Tew-George, B ;
Bayley, AJS ;
Catton, CN ;
Milosevic, MF ;
Moore, M ;
Warde, PR .
EUROPEAN UROLOGY, 2004, 45 (06) :754-760
[7]   THE EFFECT OF GRADED UNILATERAL TESTICULAR BIOPSY ON THE REPRODUCTIVE CAPACITY OF MALE-RATS [J].
COSENTINO, MJ ;
SHEINFELD, J ;
ERTURK, E ;
COCKETT, ATK .
JOURNAL OF UROLOGY, 1986, 135 (01) :155-158
[8]   Microsurgical testis biopsy: A novel technique for retrieval of testicular tissue [J].
Dardashti, K ;
Williams, RH ;
Goldstein, M .
JOURNAL OF UROLOGY, 2000, 163 (04) :1206-1207
[9]  
DELVENTO VR, 1992, AM J VET RES, V53, P2094
[10]   False-negative biopsies for the diagnosis of testicular intraepithelial neoplasia (TIN) - An update [J].
Dieckmann, KP ;
Loy, V .
EUROPEAN UROLOGY, 2003, 43 (05) :516-521