Successful Matched Related Bone Marrow Transplantation in a Patient with Autosomal Dominant Interferon Gamma Receptor 1 Deficiency

被引：1

作者：

Zerbe, Christa S. ^{[1
]}

Dimitrova, Dimana ^{[2
]}

Gea-Banacloche, Juan J. ^{[3
]}

Kreuzburg, Samantha ^{[1
]}

Holland, Steven M. ^{[1
]}

Kanakry, Jennifer A. ^{[2
]}

机构：

[1] NIAID, Lab Clin Immunol & Microbiol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[2] NCI, Expt Transplantat & Immunol Branch, NIH, Bethesda, MD 20892 USA

[3] Mayo Clin, Phoenix, AZ USA

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2020年 / 40卷 / 07期

基金：

美国国家卫生研究院;

关键词：

Interferon gamma receptor; hematopoietic cell transplant; nontuberculous mycobacteria; infection; STEM-CELL TRANSPLANTATION; CHILD;

D O I：

10.1007/s10875-020-00826-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A Summary This is a report of a successful bone marrow transplant in an IFN-gamma R1 patient with progressive mycobacterial infection. Purpose Hematopoietic cell transplant in patients with interferon gamma receptor deficiencies has been fraught with challenges, not the least of which is failure of engraftment and infectious complications. Methods This is a report of a successful hematopoietic cell transplant in an actively infected patient of advanced age. Results This case report shows successful engraftment and resolution of infection posttransplant using a matched related donor in a single institution. Conclusion A successful curative HCT despite persistent, disseminated, nontuberculous mycobacterial infection in a patient with AD-IFN gamma R1 suggests that this approach, while difficult, may be useful in other patients with otherwise refractory disease.

引用

页码：1045 / 1047

页数：3

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