Anodic oxidation reactions: the total synthesis of (+)-nemorensic acid

被引：14

作者：

Liu, B ^{[1
]}

Moeller, KD ^{[1
]}

机构：

[1] Washington Univ, Dept Chem, St Louis, MO 63130 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 41期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(01)01506-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The anodic coupling of an enol ether to an oxygen nucleophile has been used as a key step in the total synthesis of (+)-nemorensic acid. The anodic cyclization reaction allows for a reversal in the way the tetrahydrofuran ring of the natural product is normally assembled and thus enables construction of the ring in a highly stereoselective fashion. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：7163 / 7165

页数：3

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