Synthesis of α-fluoroalkyl substituted peptides via enzymatic fragment condensation

被引：28

作者：

Bordusa, F

Dahl, C

Jakubke, HD

Burger, K

Koksch, B

机构：

[1] Univ Leipzig, Dept Biochem, D-04103 Leipzig, Germany

[2] Univ Leipzig, Dept Organ Chem, D-04103 Leipzig, Germany

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0957-4166(98)00508-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A peptide library consisting of di- and tripeptide esters and tripeptide amides, respectively, containing alpha-Tfm amino acids in different positions was synthesized and tested for enzymatic fragment condensations catalyzed by the proteases alpha-chymotrypsin, trypsin and clostripain. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：307 / 313

页数：7

共 36 条

[11]

DAHL C, THESIS U LEIPZIG

[12] PEPTIDOMIMETICS FOR RECEPTOR LIGANDS DISCOVERY, DEVELOPMENT, AND MEDICAL PERSPECTIVES [J].