The long-term effect of perinatal asphyxia on hippocampal volumes

被引:38
作者
Annink, Kim, V [1 ]
de Vries, Linda S. [1 ]
Groenendaal, Floris [1 ]
van den Heuvel, Martijn P. [2 ,3 ]
van Haren, Neeltje E. M. [4 ]
Swaab, Hanna [5 ]
van Handel, Marielle [4 ]
Jongmans, Marian J. [1 ,6 ]
Benders, Manon J. [1 ]
van der Aa, Niek E. [1 ]
机构
[1] Univ Utrecht, Dept Neonatol, Brain Ctr Rudolf Magnus, Wilhelmina Childrens Hosp,Univ Med Ctr Utrecht, Utrecht, Netherlands
[2] Vrije Univ Amsterdam, Dept Complex Traits Genet, Ctr Neurogen & Cognit Res, Connectome Lab, Amsterdam, Netherlands
[3] Vrije Univ Amsterdam Med Ctr, Dept Clin Genet, Amsterdam Neurosci, Amsterdam, Netherlands
[4] Univ Utrecht, Dept Psychiat, Brain Ctr Rudolf Magnus, Univ Med Ctr Utrecht, Utrecht, Netherlands
[5] Leiden Univ, Dept Clin Child & Adolescent Studies, Leiden, Netherlands
[6] Univ Utrecht, Dept Educ & Pedag, Utrecht, Netherlands
关键词
9-TO 10-YEAR-OLD CHILDREN; NEONATAL ENCEPHALOPATHY; DEVELOPMENTAL AMNESIA; SEGMENTATION; PERFORMANCE; VULNERABILITY; SURVIVORS; ATROPHY; AGE;
D O I
10.1038/s41390-018-0115-8
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
BACKGROUND: Hypoxic-ischemic encephalopathy (HIE) in term-born infants can lead to memory problems. The hippocampus is important for long-term episodic memory. The primary aim was to investigate the effect of HIE on hippocampal volumes in 9- to 10-year-old children. The secondary aim was to investigate the association between hippocampal volumes and previously found impaired memory and cognitive functions in the current cohort. METHODS: In total 26 children with mild HIE, 26 with moderate HIE, and 37 controls were included. The intelligence quotient (IQ) and memory were tested. A 3D-volumetric MRI was obtained. Brain segmentation was performed for hippocampal volumes and intracranial volume. The differences in hippocampal volumes, memory, and IQ between the groups were determined. Multivariable linear regression analyses were performed, including hippocampal volume as a percentage of intracranial volume as a dependent variable. RESULTS: Smaller hippocampal volumes were found in moderate HIE (p < 0.001), with a trend toward smaller volumes in mild HE, compared to controls. In multivariable linear regression analysis, hippocampal volume as a percentage of intracranial volume was significantly associated with long-term visuospatial memory. CONCLUSION: Children with moderate HIE had smaller hippocampal volumes than controls, with a trend toward smaller volumes following mild HIE. Reduced hippocampal volumes were associated with poorer long-term visuospatial memory.
引用
收藏
页码:43 / 49
页数:7
相关论文
共 41 条
[1]   Correlations between regional brain volumes and memory performance in anoxia [J].
Allen, JS ;
Tranel, D ;
Bruss, J ;
Damasio, H .
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 2006, 28 (04) :457-476
[2]  
[Anonymous], 1988, Assessment of children
[3]   Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy. [J].
Azzopardi, Denis V. ;
Strohm, Brenda ;
Edwards, A. David ;
Dyet, Leigh ;
Halliday, Henry L. ;
Juszczak, Edmund ;
Kapellou, Olga ;
Levene, Malcolm ;
Marlow, Neil ;
Porter, Emma ;
Thoresen, Marianne ;
Whitelaw, Andrew ;
Brocklehurst, Peter .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (14) :1349-1358
[4]   Differential vulnerability of hippocampus, basal ganglia, and prefrontal cortex to long-term NMDA excitotoxicity [J].
Bernal, F ;
Saura, J ;
Ojuel, J ;
Mahy, N .
EXPERIMENTAL NEUROLOGY, 2000, 161 (02) :686-695
[5]  
Bleichrodt N, 1996, RAKIT REVISIE AMSTER
[6]   Neonatal Hypoxia, Hippocampal Atrophy, and Memory Impairment: Evidence of a Causal Sequence [J].
Cooper, Janine M. ;
Gadian, David G. ;
Jentschke, Sebastian ;
Goldman, Allan ;
Munoz, Monica ;
Pitts, Georgia ;
Banks, Tina ;
Chong, W. Kling ;
Hoskote, Aparna ;
Deanfield, John ;
Baldeweg, Torsten ;
de Haan, Michelle ;
Mishkin, Mortimer ;
Vargha-Khadem, Faraneh .
CEREBRAL CORTEX, 2015, 25 (06) :1469-1476
[7]   Human memory development and its dysfunction after early hippocampal injury [J].
de Haan, Michelle ;
Mishkin, Mortimer ;
Baldeweg, Torsten ;
Vargha-Khadem, Faraneh .
TRENDS IN NEUROSCIENCES, 2006, 29 (07) :374-381
[8]   Transient global ischemia in rat brain promotes different NMDA receptor regulation depending on the brain structure studied [J].
Dos-Anjos, Severiano ;
Martinez-Villayandre, Beatriz ;
Montori, Sheyla ;
Regueiro-Purrinos, Marta M. ;
Gonzalo-Orden, Jose M. ;
Fernandez-Lopez, Arsenio .
NEUROCHEMISTRY INTERNATIONAL, 2009, 54 (3-4) :180-185
[9]   Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain [J].
Fischl, B ;
Salat, DH ;
Busa, E ;
Albert, M ;
Dieterich, M ;
Haselgrove, C ;
van der Kouwe, A ;
Killiany, R ;
Kennedy, D ;
Klaveness, S ;
Montillo, A ;
Makris, N ;
Rosen, B ;
Dale, AM .
NEURON, 2002, 33 (03) :341-355
[10]   Developmental amnesia associated with early hypoxic-ischaemic injury [J].
Gadian, DG ;
Aicardi, J ;
Watkins, KE ;
Porter, DA ;
Mishkin, M ;
Vargha-Khadem, F .
BRAIN, 2000, 123 :499-507