A CpG oligodeoxynucleotide acts as a potent adjuvant for inactivated rabies virus vaccine

被引：50

作者：

Wang, Xueju ^{[2
]}

Bao, Musheng ^{[2
]}

Wan, Min ^{[2
]}

Wei, Hongfei ^{[2
]}

Wang, Li ^{[1
]}

Yu, Hongtao ^{[3
]}

Zhang, Xuesong ^{[4
]}

Yu, Yongli ^{[1
]}

Wang, Liying ^{[2
]}

机构：

[1] Jilin Univ, Coll Basic Med, Dept Immunol, Changchun 130021, Peoples R China

[2] Jilin Univ, Coll Basic Med, Dept Mol Biol, Changchun 130021, Peoples R China

[3] Changchun Inst Biol Prod, Changchun 130021, Peoples R China

[4] Blood Ctr Jilin Prov, Changchun 130033, Peoples R China

来源：

VACCINE | 2008年 / 26卷 / 15期

基金：

中国国家自然科学基金;

关键词：

CpG ODN; rabies vaccine; adjuvant;

D O I：

10.1016/j.vaccine.2008.01.043

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To develop a CpG containing oligodeoxynucleotide (CpG ODN)-enhanced rabies vaccine for stimulating an earlier production of rabies virus neutralizing antibody (RVNAb) with high titers, we designed a CpG ODN (BW006) and evaluated its adjuvant activities in enhancing the immune response to rabies vaccine with or without aluminum in mice. It was found that BW006 could facilitate the rabies vaccine to induce an earlier and more vigorous RVNAb response, resulting in more effective protection of mice from rabies virus challenge. In addition, three shots of rabies vaccine with BW006 induced compatible RVNAb level with that induced by five shots of aluminum-adjuvanted rabies vaccine. These data reveal that BW006 could be used as a promising adjuvant to replace of or combine with aluminum for developing more effective rabies vaccines. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1893 / 1901

页数：9

共 44 条

[21] KLAUS GGB, 1979, IMMUNOLOGY, V38, P687
[22] CpG oligonucleotides improve the protective immune response induced by the licensed anthrax vaccine
Klinman, Dennis M.
Xie, Hang
Ivins, Bruce E.
[J]. OLIGONUCLEOTIDE THERAPEUTICS, 2006, 1082 : 137 - 150
[23] CpG oligonucleotides accelerate and boost the immune response elicited by AVA, the licensed anthrax vaccine
Klinman, Dennis M.
[J]. EXPERT REVIEW OF VACCINES, 2006, 5 (03) : 365 - 369
[24] CPG MOTIFS IN BACTERIAL-DNA TRIGGER DIRECT B-CELL ACTIVATION
KRIEG, AM
YI, AK
MATSON, S
WALDSCHMIDT, TJ
BISHOP, GA
TEASDALE, R
KORETZKY, GA
KLINMAN, DM
[J]. NATURE, 1995, 374 (6522) : 546 - 549
[25] Krieg Arthur M, 2007, Proc Am Thorac Soc, V4, P289, DOI 10.1513/pats.200701-021AW
[26] Therapeutic potential of Toll-like receptor 9 activation
Krieg, Arthur M.
[J]. NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (06) : 471 - 484
[27] Lin H, 1999, Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi, V13, P133
[28] CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells
Liu, NS
Ohnishi, N
Ni, L
Akira, SZ
Bacon, KB
[J]. NATURE IMMUNOLOGY, 2003, 4 (07) : 687 - 693
[29] CpG oligodeoxynucleotides with hepatitis B surface antigen (HBsAg) for vaccination in HBsAg-Transgenic mice
Malanchère-Brès, E
Payette, PJ
Mancini, M
Tiollais, P
Davis, HL
Michel, ML
[J]. JOURNAL OF VIROLOGY, 2001, 75 (14) : 6482 - 6491
[30] Stimulation of thymocyte proliferation by phosphorothioate DNA oligonucleotides
Mannon, RB
Nataraj, C
Pisetsky, DS
[J]. CELLULAR IMMUNOLOGY, 2000, 201 (01) : 14 - 21

← 1 2 3 4 5 →