Humoral immune responses against SARS-CoV-2 Spike variants after mRNA vaccination in solid organ transplant recipients

被引：11

作者：

Tauzin, Alexandra ^{[1
,2
]}

Beaudoin-Bussieres, Guillaume ^{[1
,2
]}

Gong, Shang Yu ^{[1
,3
]}

Chatterjee, Debashree ^{[1
]}

Gendron-Lepage, Gabrielle ^{[1
]}

Bourassa, Catherine ^{[1
]}

Goyette, Guillaume ^{[1
]}

Racine, Normand ^{[4
]}

Khrifi, Zineb ^{[1
]}

Turgeon, Julie ^{[1
,5
]}

Tremblay, Cecile ^{[1
,2
]}

Martel-Laferriere, Valerie ^{[1
,2
]}

Kaufmann, Daniel E. ^{[1
,6
]}

Cardinal, Heloise ^{[1
,2
,5
]}

Cloutier, Marc ^{[7
]}

Bazin, Renee ^{[7
]}

Duerr, Ralf ^{[8
]}

Dieude, Melanie ^{[1
,2
,5
,7
]}

Hebert, Marie-Josee ^{[1
,5
,6
]}

Finzi, Andres ^{[1
,2
,3
]}

机构：

[1] Ctr Rech CHUM, Montreal, PQ H2X 0A9, Canada

[2] Univ Montreal, Dept Microbiol Infectiol & Immunol, Montreal, PQ H2X 0A9, Canada

[3] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ H3A 2B4, Canada

[4] Inst Cardiol Montreal, Montreal, PQ H1T 1C8, Canada

[5] Canadian Donat & Transplantat Res Program CDTRP, Edmonton, AB T6G 2E1, Canada

[6] Univ Montreal, Dept Med, Montreal, PQ H3T 1J4, Canada

[7] Hema Quebec, Affaires Med & Innovat, Quebec City, PQ G1V 5C3, Canada

[8] NYU, Sch Med, Dept Microbiol, New York, NY 10016 USA

来源：

ISCIENCE | 2022年 / 25卷 / 09期

基金：

加拿大创新基金会; 芬兰科学院;

关键词：

16-WEEK INTERVAL; COVID-19;

D O I：

10.1016/j.isci.2022.104990

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Although SARS-CoV-2mRNA vaccination has been shown to be safe and effective in the general population, immunocompromised solid organ transplant recipients (SOTRs) were reported to have impaired immune responses after one or two doses of vaccine. In this study, we examined humoral responses induced after the second and the third dose of mRNA vaccine in different SOTR (kidney, liver, lung, and heart). Compared to a cohort of SARS-CoV-2 naive immunocompetent health care workers (HCWs), the second dose induced weak humoral responses in SOTRs, except for the liver recipients. The third dose boosted these responses but they did not reach the same level as in HCW. Interestingly, although the neutralizing activity against Delta and Omicron variants remained very low after the third dose, Fc-mediated effector functions in SOTR reached similar levels as in the HCW cohort. Whether these responses will suffice to protect SOTR from severe outcome remains to be determined.

引用

页数：18

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