Long-term stability of diverse immunological memory

被引：2

作者：

Utzny, C ^{[1
]}

Burroughs, NJ ^{[1
]}

机构：

[1] Univ Warwick, Coventry CV4 7AL, W Midlands, England

来源：

JOURNAL OF THEORETICAL BIOLOGY | 2001年 / 211卷 / 04期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1006/jtbi.2001.2352

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mathematical modelling is used to examine the effects of T cell apoptosis and memory differentiation dynamics on memory retention (memory stability). Apoptosis by cytokine deprivation induced death, and competition for survival signals are incorporated. Our models indicate that such population dependent processes are essential for the preservation of specific memory to previously encountered pathogens. Memory stability and vaccination properties improve significantly when population dependent mechanisms are present. These mechanisms work synergistically together to further improve memory characteristics. Our models emphasize the role of competitive cellular mechanisms in regulating repertoire structure and characteristics. (C) 2001 Academic Press.

引用

页码：393 / 402

页数：10

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