Superantigens and SARS-CoV-2

被引:11
|
作者
Hamdy, Adam [1 ]
Leonardi, Anthony [2 ]
机构
[1] Panres Pandem Res, Newport TF10 8PG, Shrops, England
[2] Johns Hopkins Univ, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA
来源
PATHOGENS | 2022年 / 11卷 / 04期
关键词
SARS-CoV-2; COVID-19; long COVID; post-acute COVID-19 syndrome; reinfection; coronavirus; neuroinvasion; superantigen; SYSTEMIC-LUPUS-ERYTHEMATOSUS; HUMAN ENDOGENOUS RETROVIRUS; T-CELL-ACTIVATION; SHOCK-SYNDROME TOXIN-1; BACTERIAL SUPERANTIGENS; CHRONIC EXPOSURE; CLONAL DELETION; POTENTIAL ROLE; MESSENGER-RNA; DISEASE;
D O I
10.3390/pathogens11040390
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
It has been posited SARS-CoV-2 contains at least one unique superantigen-like motif not found in any other SARS or endemic coronaviruses. Superantigens are potent antigens that can send the immune system into overdrive. SARS-CoV-2 causes many of the biological and clinical consequences of a superantigen, and, in the context of reinfection and waning immunity, it is important to better understand the impact of a widely circulating, airborne pathogen that may be a superantigen, superantigen-like or trigger a superantigenic host response. Urgent research is needed to better understand the long-term risks being taken by governments whose policies enable widespread transmission of a potential superantigenic pathogen, and to more clearly define the vaccination and public health policies needed to protect against the consequences of repeat exposure to the pathogen.
引用
收藏
页数:11
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