Alternative splicing of potassium channels: a dynamic switch of cellular excitability

被引：84

作者：

Shipston, MJ ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Med, Membrane Biol Grp, Sect Biomed Sci, Edinburgh EH8 9XD, Midlothian, Scotland

来源：

TRENDS IN CELL BIOLOGY | 2001年 / 11卷 / 09期

关键词：

D O I：

10.1016/S0962-8924(01)02068-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alternative splicing of pre-messenger RNA and reversible protein phosphorylation are fundamental mechanisms for regulating protein structure and function. Recent studies of one class of potassium channel (BKCa) reveal dynamic reciprocal interactions between pre-mRNA splicing and protein phosphorylation. Splicing is regulated by phosphorylation, and exon selection determines the sensitivity of the channel protein to regulation by protein phosphorylation. These studies reveal a powerful dynamic molecular switch to determine cellular excitability.

引用

页码：353 / 358

页数：6

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