SERS-Based Molecularly Imprinted Plasmonic Sensor for Highly Sensitive PAH Detection

被引:83
作者
Castro-Grijalba, Alexander [1 ,2 ,3 ]
Montes-Garcia, Veronica [1 ,2 ]
Jose Cordero-Ferradas, Maria [1 ,2 ]
Coronado, Eduardo [3 ]
Perez-Juste, Jorge [1 ,2 ]
Pastoriza-Santos, Isabel [1 ,2 ]
机构
[1] Univ Vigo, Ctr Singular Invest Biomed CINBIO, Vigo 36310, Spain
[2] Univ Vigo, Dept Quim Fis, Vigo 36310, Spain
[3] Univ Nacl Cordoba, Fac Ciencias Quim, Ctr Laser Ciencias Mol, Dept Fisicoquim,INFIQC, RA-5000 Cordoba, Argentina
关键词
molecularly imprinted polymers; hybrid nanostructures; plasmonic sensors; SERS; polycyclic aromatic hydrocarbons; environmental analysis; POLYCYCLIC AROMATIC-HYDROCARBONS; ENHANCED RAMAN-SCATTERING; GOLD NANOPARTICLES; LABEL-FREE; POLYMER; EXTRACTION; CHEMISTRY; FILMS;
D O I
10.1021/acssensors.9b01882
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A novel hybrid plasmonic platform based on the synergetic combination of a molecularly imprinted polymer (MIP) thin film with Au nanoparticle (NPs) assemblies, noted as Au@MIP, was developed for surface-enhanced Raman scattering (SERS) spectroscopy recognition of polycyclic aromatic hydrocarbons (PAHs). While the MIP trapped the PAH close to the Au surface, the plasmonic NPs enhanced the molecule's Raman signal. The Au@MIP fabrication comprises a two-step procedure, first, the layer-by-layer deposition of Au NPs on glass and their further coating with a uniform MIP thin film. Profilometry analysis demonstrated that the thickness and homogeneity of the MIP film could be finely tailored by tuning different parameters such as prepolymerization time or spin-coating rate. Two different PAH molecules, pyrene or fluoranthene, were used as templates for the fabrication of pyrene- or fluoranthene-based Au@MIP substrates. The use of pyrene or fluoranthene, as the template molecule to fabricate the Au@MIP thin films, enabled its ultradetection in the nM regime with a 100-fold improvement compared with the nonimprinted plasmonic sensors (Au@NIPs). The SERS data analysis allowed to estimate the binding constant of the template molecule to the MIP. The selectivity of both pyrene- and fluoranthene-based Au@MIPs was analyzed against three PAHs of different sizes. The results displayed the important role of the template molecule used for the Au@MIPs fabrication in the selectivity of the system. Finally, the practical applicability of pyrene-based Au@MIPs was shown by performing the detection of pyrene in two real samples: creek water and seawater. The design and optimization of this type of plasmonic platform will pave the way for the detection of other relevant (bio)molecules in a broad range of fields such as environmental control, food safety, or biomedicine.
引用
收藏
页码:693 / 702
页数:10
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