A Metal-Free Route to Heterocyclic Trifluoromethyl- and Fluoroalkylselenolated Molecules

被引：64

作者：

Glenadel, Quentin ^{[1
]}

Ismalaj, Ermal ^{[1
]}

Billard, Thierry ^{[1
]}

机构：

[1] Univ Lyon 1, ICBMS UMR CNRS 5246, Inst Chem & Biochem, CNRS, 43 Bd 11 Novembre 1918, F-69622 Villeurbanne, France

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 01期

关键词：

CATALYZED TRIFLUOROMETHYLSELENOLATION; MEDICINAL CHEMISTRY; DRUG DISCOVERY; ALKYL-HALIDES; RING-CLOSURE; SELENIUM; FLUORINE; COPPER; ARYL; TRIFLUOROMETHANESULFANYLAMIDE;

D O I：

10.1021/acs.orglett.7b03338

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free methodology to easily synthesize various CF3Se-containing heterocyclic compounds has been developed through intramolecular ring closures of alkynes promoted with CF3SeCl. Moreover, this strategy has also been extended to other fluoroalkylselenyl groups.

引用

收藏

页码：56 / 59

页数：4

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