Fact or Fiction? Adipose-Derived Stem Cells and Platelet-Rich Plasma for the Treatment of Vulvar Lichen Sclerosus

被引：25

作者：

Eshtiaghi, Panteha ^{[1
]}

Sadownik, Leslie Ann ^{[2
,3
]}

机构：

[1] Univ British Columbia, Fac Med, Vancouver, BC, Canada

[2] Univ British Columbia, Div Gynecol Oncol, Dept Obstet & Gynecol, Vancouver, BC, Canada

[3] BC Ctr Vulvar Hlth, Vancouver, BC, Canada

来源：

JOURNAL OF LOWER GENITAL TRACT DISEASE | 2019年 / 23卷 / 01期

关键词：

vulvar; lichen sclerosus; stem cells; MANAGEMENT;

D O I：

10.1097/LGT.0000000000000440

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective The aim of the study was to summarize and review the evidence for the efficacy and safety of adipose-derived stem cells (ADSCs) and platelet-rich plasma (PRP) for the treatment of vulvar lichen sclerosus (LS). Materials and Methods PubMed/MEDLINE, Ovid, Web of Science, and were searched from inception up to May 7, 2018. Results Seven observational studies were identified, with a total of 98 patients. Both ADSCs and PRP were reported to improve symptoms, quality of life measures, as well as clinical and histological signs of vulvar LS. There is a strong risk of biased estimates of treatment effect. Conclusions Current evidence is weak for ADSCs and/or PRP as treatment for vulvar LS. Further research is needed before recommending this therapy.

引用

页码：65 / 70

页数：6

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