Rhabdomyosarcomagenesis - Novel pathway found

被引：6

作者：

Asakura, A

Rudnicki, MA

机构：

[1] Univ Minnesota, Div Cardiovasc, Dept Med, Sch Med, Minneapolis, MN 55455 USA

[2] Ottawa Hlth Res Inst, Mol Med Program, Ottawa, ON K1H 8L6, Canada

来源：

CANCER CELL | 2003年 / 4卷 / 06期

关键词：

D O I：

10.1016/S1535-6108(03)00313-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Recent work presented in this issue of Cancer Cell by Fleischmann et al. on gene knockout mice revealed a remarkable molecular pathway for rhabdomyosarcomagenesis, in which Trp53/Fos double mutant mice developed RMS of the facial and orbital regions with high penetrance. This finding may provide novel molecular mechanisms for Rhabdomyosarcomagenesis and therapeutic implications for RMS patients.

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收藏

页码：421 / 422

页数：2

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