DNA methylation at H19/IGF2 ICR1 in the placenta of pregnancies conceived by in vitro fertilization and intracytoplasmic sperm injection

被引：38
作者：
Wong, Edgar Chan [1 ]
Hatakeyama, Chiho [1 ]
Robinson, Wendy P. [2 ]
Ma, Sai [1 ]
机构：
[1] Univ British Columbia, Dept Obstet & Gynaecol, Vancouver, BC V5Z 1M9, Canada
[2] Univ British Columbia, Dept Med Genet, Vancouver, BC V5Z 1M9, Canada
来源：
FERTILITY AND STERILITY | 2011年 / 95卷 / 08期
关键词：
DNA methylation; H19; ICR1; IGF2; placenta; IVF; ICSI; small for gestational age; ASSISTED REPRODUCTIVE TECHNOLOGIES; INTRAUTERINE GROWTH RESTRICTION; BECKWITH-WIEDEMANN-SYNDROME; IMPRINTING CONTROL REGION; FOR-GESTATIONAL-AGE; ABNORMAL METHYLATION; BIRTH-WEIGHT; EXPRESSION; IVF/ICSI; OOCYTES;
D O I：
10.1016/j.fertnstert.2011.05.047
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
DNA methylation at H19 ICR1 was investigated in the placenta from pregnancies conceived by in vitro fertilization, intracytoplasmic sperm injection, and from natural conception. Our results showed that there were no significant differences in mean methylation between all pregnancy groups; therefore, assisted reproductive technology may not affect proper imprinting of H19 and IGF2. (Fertil Steril (R) 2011; 95: 2524-6. (c) 2011 by American Society for Reproductive Medicine.)
引用
收藏
页码：2524 / U544
页数：6
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