Crystal, molecular structure, and conformational preferences of 3-(2-(4-morpholinophenyl)-2-oxoethyl)-5,5-diphenylimidazolidine-2,4-dione

被引：1
作者：
Abdel-Aziz, Alaa A-M. [1 ,2 ]
Ghabbour, Hazem A. [1 ,2 ]
El-Azab, Adel S. [1 ,3 ]
Khalil, Nasr Y. [1 ]
Fun, Hoong-Kun [1 ]
El-Sherbeny, Magda A. [2 ,4 ]
机构：
[1] King Saud Univ, Dept Pharmaceut Chem, Coll Pharm, Riyadh 11451, Saudi Arabia
[2] Univ Mansoura, Dept Med Chem, Fac Pharm, Mansoura 35516, Egypt
[3] Al Azhar Univ, Dept Organ Chem, Fac Pharm, Cairo, Egypt
[4] Delta Univ Sci & Technol, Dept Pharmaceut Chem, Coll Pharm, Gamasa City, Egypt
来源：
MOLECULAR CRYSTALS AND LIQUID CRYSTALS | 2016年 / 631卷 / 01期
关键词：
Imidazolidine-2; 4-dione; UV-spectra; X-ray crystal structure; crystal pack; conformers; INTERMOLECULAR INTERACTIONS; DESIGN; HYDANTOINS; SPECTRUM; FEATURES; MOTIF; UREA;
D O I：
10.1080/15421406.2016.1149027
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The X-ray crystal structure of 3-(2-(4-morpholinophenyl)-2-oxoethyl)-5,5-diphenylimidazolidine-2,4-dione (2) [C27H25N3O4: MF = 455.50, monoclinic, P2(1)/c, a = 6.2038 (2) angstrom, b = 20.8905 (6) angstrom, c = 18.3361 (6) angstrom, b = 97.594 (2), V = 2355.53 angstrom(3), Z = 4, D-calc = 1.284 Mg m(-3), = 1.54178 angstrom] was determined. The crystal packing confirmed the occurrence of two conformers of opposite conformation. Conformational aspects of compound 2 have pointed out two factors that determine the conformation of the system under investigation: first, the intermolecular hydrogen bonding of the crystal packing, which stabilizes and favors the occurrence of two independent molecules, and the second factor is the steric hindrance among substituents.
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收藏
页码：144 / 153
页数：10
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