Crystal, molecular structure, and conformational preferences of 3-(2-(4-morpholinophenyl)-2-oxoethyl)-5,5-diphenylimidazolidine-2,4-dione

被引：1

作者：

Abdel-Aziz, Alaa A-M. ^{[1
,2
]}

Ghabbour, Hazem A. ^{[1
,2
]}

El-Azab, Adel S. ^{[1
,3
]}

Khalil, Nasr Y. ^{[1
]}

Fun, Hoong-Kun ^{[1
]}

El-Sherbeny, Magda A. ^{[2
,4
]}

机构：

[1] King Saud Univ, Dept Pharmaceut Chem, Coll Pharm, Riyadh 11451, Saudi Arabia

[2] Univ Mansoura, Dept Med Chem, Fac Pharm, Mansoura 35516, Egypt

[3] Al Azhar Univ, Dept Organ Chem, Fac Pharm, Cairo, Egypt

[4] Delta Univ Sci & Technol, Dept Pharmaceut Chem, Coll Pharm, Gamasa City, Egypt

来源：

MOLECULAR CRYSTALS AND LIQUID CRYSTALS | 2016年 / 631卷 / 01期

关键词：

Imidazolidine-2; 4-dione; UV-spectra; X-ray crystal structure; crystal pack; conformers; INTERMOLECULAR INTERACTIONS; DESIGN; HYDANTOINS; SPECTRUM; FEATURES; MOTIF; UREA;

D O I：

10.1080/15421406.2016.1149027

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The X-ray crystal structure of 3-(2-(4-morpholinophenyl)-2-oxoethyl)-5,5-diphenylimidazolidine-2,4-dione (2) [C27H25N3O4: MF = 455.50, monoclinic, P2(1)/c, a = 6.2038 (2) angstrom, b = 20.8905 (6) angstrom, c = 18.3361 (6) angstrom, b = 97.594 (2), V = 2355.53 angstrom(3), Z = 4, D-calc = 1.284 Mg m(-3), = 1.54178 angstrom] was determined. The crystal packing confirmed the occurrence of two conformers of opposite conformation. Conformational aspects of compound 2 have pointed out two factors that determine the conformation of the system under investigation: first, the intermolecular hydrogen bonding of the crystal packing, which stabilizes and favors the occurrence of two independent molecules, and the second factor is the steric hindrance among substituents.

引用

页码：144 / 153

页数：10

共 50 条

[31] Synthesis and Crystal Structure of (E)-2-(3,4,5-Trimethoxystyryl)-5-nitrobenzenesulfonate Pyrrolidinium
Liang, Bo
Ji, Wen-Ting
Wang, Sheng-Hui
Hu, Ting-Ting
JOURNAL OF CHEMICAL CRYSTALLOGRAPHY, 2019, 49 (03) : 181 - 185
[32] Theoretical investigations on the molecular structure, vibrational spectra, HOMO-LUMO analyses and NBO study of 1-[(Cyclopropylmethoxy)methyl]-5-ethyl-6-(4-methylbenzyl)-1, 2,3,4-tetrahydropyrimidine-2,4-dione
Al-Abdullah, Ebtehal S.
Mary, Y. Sheena
Panicker, C. Yohannan
El-Brollosy, Nasser R.
El-Emam, Ali A.
Van Alsenoy, Christian
Al-Saadi, Abdulaziz A.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2014, 133 : 639 - 650
[33] Synthesis and structure-activity relationship studies on novel 8-amino-3-[2-(4-fluorophenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione derivatives as anticonvulsant agents
Madaiah, M.
Prashanth, M. K.
Revanasiddappa, H. D.
Veeresh, B.
MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (06) : 2633 - 2644
[34] Novel one-pot multicomponent synthesis of (E)-2-(benzylideneamino)-5-mercapto-4H-1,2,4-triazol-3-yl)-2,3-dihydrophthalazine-1,4-dione derivatives
Sujatha, Kodam
Vedula, Rajeswar Rao
SYNTHETIC COMMUNICATIONS, 2020, 50 (01) : 129 - 135
[35] Crystal structure of 3-(2-(5-(4-fluorophenyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4-yl)-2H-chromen-2-one, C28H20FN3O2S
Alotibi, Mohammed F.
Abdel-Wahab, Bakr F.
Yousif, Emad
Hegazy, Amany S.
Kariuki, Benson M.
El-Hiti, Gamal A.
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2020, 235 (02): : 469 - 471
[36] Crystal structure of 6-(phenylsulfanyl)-5-propylpyrimidine-2,4(1H,3H)- dione, C13H14N2O2S
Al-Omary, Fatmah A. M.
Ghabbour, Hazem A.
Attia, Mohamed I.
Fun, Hoong-Kun
El-Emam, Ali A.
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2015, 230 (03): : 289 - 291
[37] Crystal structure, Hirshfeld surface analysis and interaction energy and DFT studies of 3-{(2Z)-2-[(2,4-dichlorophenyl)methylidene]-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-4-yl}propanenitrile
Kheira Sebbar, Nada
Hni, Brahim
Hokelek, Tuncer
Jaouhar, Abdelhakim
Labd Taha, Mohamed
Mague, Joel T.
Mokhtar Essassi, El
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2019, 75 : 721 - +
[38] Crystal Structure of 2-(Pyridin-4-yl)-5-(Undecylthio)-1,3,4-Oxadiazole
Shen, Z. -H.
Wang, Q.
Sun, Z. -H.
Wu, H. -K.
Tan, C. -X.
Weng, J. -Q.
Liu, X. -H.
JOURNAL OF STRUCTURAL CHEMISTRY, 2018, 59 (05) : 1236 - 1240
[39] Crystal structure of (2E)-2-[1-(4-bromophenyl)-3-(1H-imidazol-1-yl) propylidene]-N-(2,4-dichlorophenyl) hydrazinecarboxamide, C19H16BrCl2N5O
Al-Wabli, Reem I.
Attia, Mohamed I.
Ghabbour, Hazem A.
El-Sayed, Nahed N. E.
Fun, Hoong-Kun
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2015, 230 (03): : 217 - 218
[40] Molecular and Crystalline Structure of 6,6'‐Dimethyl‐2,3,4,5,6,7‐Hexahydrobenzo[b]Furan‐3,4‐Dione
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus
不详
220072, Belarus
不详
Journal of Applied Spectroscopy, 2001, 68 (03) : 394 - 400

← 1 2 3 4 5 →