Crystal, molecular structure, and conformational preferences of 3-(2-(4-morpholinophenyl)-2-oxoethyl)-5,5-diphenylimidazolidine-2,4-dione

被引：1
|
作者：
Abdel-Aziz, Alaa A-M. [1 ,2 ]
Ghabbour, Hazem A. [1 ,2 ]
El-Azab, Adel S. [1 ,3 ]
Khalil, Nasr Y. [1 ]
Fun, Hoong-Kun [1 ]
El-Sherbeny, Magda A. [2 ,4 ]
机构：
[1] King Saud Univ, Dept Pharmaceut Chem, Coll Pharm, Riyadh 11451, Saudi Arabia
[2] Univ Mansoura, Dept Med Chem, Fac Pharm, Mansoura 35516, Egypt
[3] Al Azhar Univ, Dept Organ Chem, Fac Pharm, Cairo, Egypt
[4] Delta Univ Sci & Technol, Dept Pharmaceut Chem, Coll Pharm, Gamasa City, Egypt
来源：
MOLECULAR CRYSTALS AND LIQUID CRYSTALS | 2016年 / 631卷 / 01期
关键词：
Imidazolidine-2; 4-dione; UV-spectra; X-ray crystal structure; crystal pack; conformers; INTERMOLECULAR INTERACTIONS; DESIGN; HYDANTOINS; SPECTRUM; FEATURES; MOTIF; UREA;
D O I：
10.1080/15421406.2016.1149027
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The X-ray crystal structure of 3-(2-(4-morpholinophenyl)-2-oxoethyl)-5,5-diphenylimidazolidine-2,4-dione (2) [C27H25N3O4: MF = 455.50, monoclinic, P2(1)/c, a = 6.2038 (2) angstrom, b = 20.8905 (6) angstrom, c = 18.3361 (6) angstrom, b = 97.594 (2), V = 2355.53 angstrom(3), Z = 4, D-calc = 1.284 Mg m(-3), = 1.54178 angstrom] was determined. The crystal packing confirmed the occurrence of two conformers of opposite conformation. Conformational aspects of compound 2 have pointed out two factors that determine the conformation of the system under investigation: first, the intermolecular hydrogen bonding of the crystal packing, which stabilizes and favors the occurrence of two independent molecules, and the second factor is the steric hindrance among substituents.
引用
收藏
页码：144 / 153
页数：10
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