Peroxisome proliferator-activated receptors (PPARs) and their role in the vessel wall: possible mediators of cardiovascular risk?

被引：43

作者：

Marx, N

Libby, P

Plutzky, J

机构：

[1] Harvard Univ, Leducq Ctr Cardiovasc Res, Div Cardiovasc,Dept Med, Brigham & Womens Hosp,Sch Med, Boston, MA 02115 USA

[2] Univ Ulm, Dept Internal Med Cardiol 2, D-89069 Ulm, Germany

来源：

JOURNAL OF CARDIOVASCULAR RISK | 2001年 / 8卷 / 04期

关键词：

atherogenesis; inflammation; PPARs; vasculature;

D O I：

10.1097/00043798-200108000-00004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Peroxisome proliferator-activated receptors (PPARs) are nuclear transcription factors that regulate gene expression in response to activation by specific ligands including insulin sensitizing thiazolidinedione and lipid-lowering fibrates. Recent work has identified PPAR alpha and PPAR gamma expression in vascular cells and established a role for these receptors in the regulation of genes relevant to atherogenesis. The following review will focus on the role of PPAR activation in the vasculature and discuss the potential clinical implications of these findings. J Cardiovasc Risk 8:203-210 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：203 / 210

页数：8

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