Deformylation reaction-based probe for in vivo imaging of HOCl

被引：194

作者：

Wei, Peng ^{[1
]}

Yuan, Wei ^{[1
]}

Xue, Fengfeng ^{[1
]}

Zhou, Wei ^{[1
]}

Li, Ruohan ^{[1
]}

Zhang, Datong ^{[2
]}

Yi, Tao ^{[1
]}

机构：

[1] Fudan Univ, Collaborat Innovat Ctr Chem Energy Mat, Dept Chem, 220 Handan Rd, Shanghai 200433, Peoples R China

[2] Qilu Univ Technol, Sch Chem & Pharmaceut Engn, Shandong Prov Key Lab Fine Chem, Jinan 250353, Shandong, Peoples R China

来源：

CHEMICAL SCIENCE | 2018年 / 9卷 / 02期

关键词：

RATIOMETRIC FLUORESCENT-PROBE; HIGHLY SELECTIVE DETECTION; HYPOCHLOROUS ACID; METHYLENE-BLUE; LIVING CELLS; LIVE CELLS; HYDROGEN-PEROXIDE; CYANINE DYE; TURN-ON; OXIDATION;

D O I：

10.1039/c7sc03784h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The detection of hypochlorous acid (HOCl) in vivo is vitally important because the local concentration of HOCl is highly correlated with some diseases such as atherosclerosis and rheumatoid arthritis. However, in vivo detection of HOCl remains a challenge due to the lack of a suitable probe. We report here a near-infrared (NIR) emissive "turn-on" probe (FDOCl-1) based on a methylene blue derivative, which can quickly detect HOCl via a newly found deformylation mechanism. FDOCl-1 displays remarkable selectivity and sensitivity towards HOCl. The dramatic changes in colour and NIR emission were used to detect HOCl in vitro and in vivo in a mouse arthritis model.

引用

页码：495 / 501

页数：7

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