Inhibition of orotidine 5′-monophosphate decarboxylase and its therapeutic potential

被引：0

作者：

Meza-Avina, M. E. ^{[1
]}

Wei, L. ^{[1
]}

Buhendwa, M. G. ^{[1
]}

Poduch, E. ^{[1
]}

Bello, A. M. ^{[1
]}

Pai, E. F. ^{[2
,3
,4
,5
]}

Kotra, L. P. ^{[1
,6
,7
]}

机构：

[1] Toronto Gen Hosp, Toronto Gen Res Inst, Ctr Mol Design & Performulat, Toronto, ON M5G 2C4, Canada

[2] Margaret Hosp, Ontario Canc Inst, Div Canc Genom & Proteom, Toronto, ON M5G 2M9, Canada

[3] Univ Toronto, Dept Med Biophys, Toronto, ON M5S 1A8, Canada

[4] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada

[5] Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5S 1A8, Canada

[6] Univ Toronto, McLaughlin Ctr Mol Med, Toronto, ON, Canada

[7] Univ N Carolina, Dept Chem & Biochem, Greensboro, NC 27412 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 03期

关键词：

orotidine 5 '-monophosphate decarboxylase; de novo nucleotide synthesis; pyrimidine nucleotides; drug design;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Orotidine 5 '-monophosphate decarboxylase (ODCase) is among the most proficient enzymes, and catalyzes the decarboxylation of OMP to UMP. An overview of ODCase and various proposals for its catalytic mechanism of decarboxylation are briefly presented here. A number of inhibitors of ODCase and new developments in the X-ray structures of ODCases from different species are discussed in the context of their therapeutic potential against cancer and infectious diseases. Latest discoveries in the inhibition of ODCase, for example using the novel C6 substitutions on the uridine, open new doors for drug discovery targeting parasitic diseases such as malaria.

引用

页码：239 / 247

页数：9

共 56 条

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