Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis

被引:97
作者
Li, Xue [1 ]
Liu, Jie [1 ]
Zuo, Tian-tian [1 ]
Hu, Ying [1 ]
Li, Zheng [1 ,2 ]
Wang, Hong-da [1 ]
Xu, Xiao-yan [1 ]
Yang, Wen-zhi [1 ]
Guo, De-an [1 ,3 ]
机构
[1] Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin Key Lab TCM Chem & Anal, 10 Poyanghu Rd, Tianjin 301617, Peoples R China
[2] Tianjin Univ Tradit Chinese Med, Coll Pharmaceut Engn Tradit Chinese Med, Tianjin 301617, Peoples R China
[3] Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, 501 Haike Rd, Shanghai 201203, Peoples R China
基金
中国国家自然科学基金;
关键词
PERFORMANCE LIQUID-CHROMATOGRAPHY; PANAX-NOTOGINSENG-SAPONINS; TANDEM MASS-SPECTROMETRY; DAMMARANE-TYPE SAPONINS; NONTARGETED METABOLOMICS APPROACH; LINEAR ION-TRAP; Q-TOF-MS/MS; MICROBIOTA-MEDIATED BIOTRANSFORMATION; NATURAL COMPOUNDS CHARACTERIZATION; HUMAN INTESTINAL MICROFLORA;
D O I
10.1039/d1np00071c
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Covering: 2011 to the end of 2020 Panax species (Araliaceae), particularly P. ginseng, P. quinquefolius, and P. notoginseng, have a long history of medicinal use because of their remarkable tonifying effects, and currently serve as crucial sources for various healthcare products, functional foods, and cosmetics, aside from their vast clinical preparations. The huge market demand on a global scale prompts the continuous prosperity in ginseng research concerning the discovery of new compounds, precise quality control, ADME (absorption/disposition/metabolism/excretion), and biosynthesis pathways. Benefitting from the ongoing rapid development of analytical technologies, e.g. multi-dimensional chromatography (MDC), personalized mass spectrometry (MS) scan strategies, and multi-omics, highly recognized progress has been made in driving ginseng analysis towards "systematicness, integrity, personalization, and intelligentization". Herein, we review the advances in the phytochemistry, quality control, metabolism, and biosynthesis pathway of ginseng over the past decade (2011-2020), with 410 citations. Emphasis is placed on the introduction of new compounds isolated (saponins and polysaccharides), and the emerging novel analytical technologies and analytical strategies that favor ginseng's authentic use and global consumption. Perspectives on the challenges and future trends in ginseng analysis are also presented.
引用
收藏
页码:875 / 909
页数:35
相关论文
共 407 条
  • [1] Localization of ginsenosides in Panax ginseng with different age by matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry imaging
    Bai, Hangrui
    Wang, Shujuan
    Liu, Jianjun
    Gao, Dan
    Jiang, Yuyang
    Liu, Hongxia
    Cai, Zongwei
    [J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2016, 1026 : 263 - 271
  • [2] Pharmacokinetic interaction of calcitriol with 20(S)-protopanaxadiol in mice: Determined by LC/MS analysis
    Ben-Eltriki, Mohamed
    Hassona, Mohamed
    Meckling, Gray
    Adomat, Hans
    Deb, Subrata
    Guns, Emma S. Tomlinson
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 130 : 173 - 180
  • [3] Plant triterpenoid saponins: biosynthesis, in vitro production, and pharmacological relevance
    Biswas, Tanya
    Dwivedi, Upendra N.
    [J]. PROTOPLASMA, 2019, 256 (06) : 1463 - 1486
  • [4] Rapid determination of Panax ginseng by near-infrared spectroscopy
    Bu Haibo
    Nie Lixing
    Wang Dan
    Yuan Shaoxiong
    Li Shan
    Guo Zhiyong
    Xu Xiaojia
    Wang Gangli
    Li Xiangri
    [J]. ANALYTICAL METHODS, 2013, 5 (23) : 6715 - 6721
  • [5] Panax ginseng polysaccharide suppresses metastasis via modulating Twist expression in gastric cancer
    Cai, Jian-Ping
    Wu, Yang-Jiazi
    Li, Cong
    Feng, Mei-Yan
    Shi, Qing-Tao
    Li, Rui
    Wang, Zhen-Yu
    Geng, Jing-Shu
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2013, 57 : 22 - 25
  • [6] An UFLC-MS/MS Method for Quantification of Panaxadiol in Rat Plasma and Its Application to a Pharmacokinetic Study
    Cai Xiaojun
    Xu Yuping
    Pan Yu
    Ren Yiping
    Xiang Zheng
    [J]. PLANTA MEDICA, 2013, 79 (14) : 1324 - 1328
  • [7] Bioactive Constituents from the Roots of Panax japonicus var. major and Development of a LC-MS/MS Method for Distinguishing between Natural and Artifactual Compounds
    Chan, Hsiu-Hui
    Hwang, Tsong-Long
    Reddy, Mopur Vijaya Bhaskar
    Li, Ding-Tzai
    Qian, Keduo
    Bastow, Kenneth F.
    Lee, Kuo-Hsiung
    Wu, Tian-Shung
    [J]. JOURNAL OF NATURAL PRODUCTS, 2011, 74 (04): : 796 - 802
  • [8] Structural analysis of water-soluble polysaccharides isolated from Panax notoginseng
    Chan, Mi Kaythi
    Yu, Yang
    Wulamu, Saideaihemaiti
    Wang, Yuan
    Wang, Qidi
    Zhou, Yifa
    Sun, Lin
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 155 (155) : 376 - 385
  • [9] Nontargeted metabolomics approach for the differentiation of cultivation ages of mountain cultivated ginseng leaves using UHPLC/QTOF-MS
    Chang, Xiangwei
    Zhang, Juanjuan
    Li, Dekun
    Zhou, Dazheng
    Zhang, Yuling
    Wang, Jincheng
    Hu, Bing
    Ju, Aichun
    Ye, Zhengliang
    [J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2017, 141 : 108 - 122
  • [10] Qualitative and Quantitative Analysis of the Major Constituents in Shexiang Tongxin Dropping Pill by HPLC-Q-TOF-MS/MS and UPLC-QqQ-MS/MS
    Chen, Daxin
    Lin, Shan
    Xu, Wen
    Huang, Mingqing
    Chu, Jianfeng
    Xiao, Fei
    Lin, Jiumao
    Peng, Jun
    [J]. MOLECULES, 2015, 20 (10) : 18597 - 18619