The molecular biology of axon guidance

被引：2614
作者：
TessierLavigne, M [1 ]
Goodman, CS [1 ]
机构：
[1] UNIV CALIF BERKELEY, HOWARD HUGHES MED INST, DEPT MOL & CELL BIOL, BERKELEY, CA 94720 USA
来源：
SCIENCE | 1996年 / 274卷 / 5290期
关键词：
D O I：
10.1126/science.274.5290.1123
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Neuronal growth cones navigate over long distances along specific pathways to find their correct targets. The mechanisms and molecules that direct this pathfinding are the topics of this review. Growth cones appear to be guided by at least four different mechanisms: contact attraction, chemoattraction, contact repulsion, and chemorepulsion. Evidence is accumulating that these mechanisms act simultaneously and in a coordinated manner to direct pathfinding and that they are mediated by mechanistically and evolutionarily conserved ligand-receptor systems.
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页码：1123 / 1133
页数：11
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