Gut microbiota and the paradox of cancer immunotherapy

被引：25

作者：

Poutahidis, Theofilos ^{[1
,2
]}

Kleinewietfeld, Markus ^{[3
,4
,5
,6
,7
]}

Erdman, Susan E. ^{[1
]}

机构：

[1] MIT, Div Comparat Med, Cambridge, MA 02139 USA

[2] Aristotle Univ Thessaloniki, Fac Vet Med, Pathol Lab, GR-54006 Thessaloniki, Greece

[3] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA

[4] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06510 USA

[5] MIT, Broad Inst, Cambridge, MA 02139 USA

[6] Harvard Univ, Cambridge, MA 02138 USA

[7] Tech Univ Dresden, Fac Med, Dresden, Germany

来源：

FRONTIERS IN IMMUNOLOGY | 2014年 / 5卷

基金：

美国国家卫生研究院;

关键词：

tumor macroenvironment; regulatory T-cells; cancer immunotherapy; inflammation and cancer; probiotic bacteria; REGULATORY T-CELLS; PROGNOSTIC-SIGNIFICANCE; CTLA4; BLOCKADE; INFLAMMATION; LYMPHOCYTES; CARCINOGENESIS; EFFECTOR; EXPRESSION; MAMMARY; TUMORS;

D O I：

10.3389/fimmu.2014.00157

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is recently shown that beneficial environmental microbes stimulate integrated immune and neuroendocrine factors throughout the body, consequently modulating regulatory T-lymphocyte phenotypes, maintaining systemic immune balance, and determining the fate of preneoplastic lesions toward regression while sustaining whole body good health. Stimulated by a gut microbiota-centric systemic homeostasis hypothesis, we set out to explore the influence of the gut microbiome to explain the paradoxical roles of regulatory T-lymphocytes in cancer development and growth. This paradigm shift places cancer prevention and treatment into a new broader context of holobiont engineering to cultivate a tumor-suppressive macroenvironment.

引用

页码：1 / 5

页数：5

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