Synthesis of (R)-, (S)-, and (RS)-hydroxymethylmexiletine, one of the major metabolites of mexiletine

被引：34

作者：

Cavalluzzi, Maria Maddalena ^{[1
]}

Catalano, Alessia ^{[1
]}

Bruno, Claudio ^{[1
]}

Lovece, Angelo ^{[1
]}

Carocci, Alessia ^{[1
]}

Corbo, Filomena ^{[1
]}

Franchini, Carlo ^{[1
]}

Lentini, Giovanni ^{[1
]}

Tortorella, Vincenzo ^{[1
]}

机构：

[1] Univ Studi Bari, Dipartimento Farmacochim, I-70125 Bari, Italy

来源：

TETRAHEDRON-ASYMMETRY | 2007年 / 18卷 / 20期

关键词：

D O I：

10.1016/j.tetasy.2007.10.002

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Hydroxymethylmexiletine (HMM), one of the main metabolites of mexiletine, has been synthesized in both racemic and optically active forms following two alternative routes. The ee values for both HMM enantiomers were 98%, as assessed by H-1 NMR analysis in the presence of (-)-(R)-(2-naphthyloxy) phenylacetic acid as a chiral solvating agent and electrophoretic analysis using beta-cyclodextrine sulfated sodium salt as a chiral auxiliary. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2409 / 2417

页数：9

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