Synthesis of 4-Aryl Isoquinolinedione Derivatives by a Palladium-Catalyzed Coupling Reaction of Aryl Halides with Isoquinoline-1,3(2H,4H)-diones

被引：16

作者：

Yang, Yuanyong ^{[1
,2
]}

Li, Yingxian ^{[1
]}

Cheng, Cheng ^{[1
]}

Yang, Guo ^{[1
]}

Zhang, Jiquan ^{[1
,2
]}

Zhang, Yi ^{[1
,2
]}

Zhao, Yonglong ^{[1
,2
]}

Zhang, Lin ^{[1
,2
]}

Li, Chun ^{[1
,2
]}

Tang, Lei ^{[2
,3
]}

机构：

[1] Guizhou Med Univ, Sch Pharm, Guiyang 550004, Guizhou, Peoples R China

[2] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Guizhou, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 06期

基金：

中国国家自然科学基金;

关键词：

TETRAHYDROISOQUINOLINE ALKALOIDS; ACTIVATED ALKENES; C-C; CHEMISTRY; ARYLATION;

D O I：

10.1021/acs.joc.7b02961

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The palladium-catalyzed cross-coupling reaction of aryl halides with isoquinoline-1,3(2H,4H)-diones for the synthesis of 4-aryl isoquinoline-1,3(2H,4H)-diones was developed. The reaction conditions exhibit remarkable compatibility with various aryl halides and isoquinoline-1,3(2H,4H)-diones, and the product could be conveniently transformed to 4-aryl tetrahydroisoquinolines. (+/-) Dichlorofensine was synthesized using this protocol in two steps with an overall yield of 71%.

引用

页码：3348 / 3353

页数：6

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