Apoptosis and traumatic brain injury

被引：62
作者：
Wong, J
Hoe, NW
Feng, ZW
Ng, I
机构：
[1] Natl Inst Neurosci, Dept Neurosurg, Clin Staff Off, Acute Brain Injury Res Lab, Singapore 308433, Singapore
[2] Natl Inst Neurosci, Dept Res, Singapore 308433, Singapore
来源：
NEUROCRITICAL CARE | 2005年 / 3卷 / 02期
关键词：
traumatic brain injury; apoptosis; Fas; caspases; Bcl-2; family; therapeutic intervention;
D O I：
10.1385/NCC:3:2:177
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Traumatic brain injury is a cause of high mortality and morbidity and is an area of intense research. Apoptosis plays a crucial role in the pathogenesis of head injury, and the inhibition of apoptosis can potentially reverse the deleterious effects and lead to better functional outcome. Elucidation of the apoptotic pathway and its role in traumatic brain injury will provide potential targets for therapeutic intervention. This article aims to review the current wealth of literature on apoptosis and traumatic head injury and explores the current status of therapeutic strategies available.
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收藏
页码：177 / 182
页数：6
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