Facile Synthesis of Isoniazid Derivatives-1-[2-(3-Aryl(Hetaryl)-1-Phenyl-1H-Pyrazol-4-yl)-5-(Pyridin-4-yl)-1,3,4-Oxadiazol-3(2H)-yl]Ethanones

被引：1

作者：

Chaudhry, Faryal ^{[1
,2
]}

Munawar, Munawar Ali ^{[2
]}

Khan, Misbahul Ain ^{[2
,3
]}

机构：

[1] Kinnaird Coll Women Lahore, Dept Chem, 93 Jail Rd, Lahore 54000, Pakistan

[2] Univ Punjab, Inst Chem, Quaid E Azam Campus, Lahore 54590, Pakistan

[3] Islamia Univ Bahawalpur Pakistan, Dept Chem, Bahawalpur 63100, Pakistan

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2020年 / 56卷 / 05期

关键词：

acylhydrazones; coumarins; hetaryloxadiazoles; isoniazid; ultrasonication; 1,3,4-OXADIAZOLE DERIVATIVES; BIOLOGICAL EVALUATION; PYRAZOLE ANALOGS; ULTRASOUND; DESIGN;

D O I：

10.1007/s10593-020-02708-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and efficient ultrasound-aided approach has afforded cyclization of isoniazid hydrazones into 2,5-bishetaryloxadiazolines at ambient temperature. Acetic anhydride helped in intramolecular oxidative cyclization along withN-acylation of oxadiazoline. The synthesized 1-[2-(1-phenyl-1H-pyrazol-4-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl]ethanones were isolated in good yields, spectral data supported the proposed structures.

引用

页码：615 / 618

页数：4

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