SIDE EFFECTS OF THE IMMUNE SYSTEM: LESSONS FROM TUBERCULOSIS-RELATED IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME

被引：0
作者：
Buonsenso, D. [1 ]
Pirronti, T. [2 ]
Genovese, O. [3 ]
Gargiullo, L. [1 ]
Ranno, O. [1 ]
Valentini, P. [1 ]
机构：
[1] Univ Cattolica Sacro Cuore, A Gemelli Hosp, Dept Pediat, I-00168 Rome, Italy
[2] Univ Cattolica Sacro Cuore, A Gemelli Hosp, Dept Bioimaging & Radiol Sci, I-00168 Rome, Italy
[3] Univ Cattolica Sacro Cuore, A Gemelli Hosp, Dept Anesthesiol & Intens Care, I-00168 Rome, Italy
来源：
EUROPEAN JOURNAL OF INFLAMMATION | 2012年 / 10卷 / 01期
关键词：
IRIS; TB; HIV; immune system; ACTIVE ANTIRETROVIRAL THERAPY; VIRUS-INFECTED CHILDREN; MYCOBACTERIUM-TUBERCULOSIS; UGANDAN CHILDREN; HIV-INFECTION; T-CELLS; MACROPHAGES; EXPRESSION; GRANULOMAS; BIOMARKERS;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immune reconstitution inflammatory syndrome (IRIS) is a recently described syndrome among human immunodeficiency virus (HIV)-infected patients attributable to the recovery of the immune system during antiretroviral therapy. A growing number of researches on this syndrome have been conducted in recent years, but IRIS in children has not been widely studied. We report the case of a 4.5 month-old, tuberculosis (TB)-HIV co-infected girl who developed IRIS two months after beginning antiretroviral and anti-TB medications. We moreover review the immunopathogenesis of TB-HIV coinfection and IRIS, with particular regard to TB-related IRIS.
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页码：1 / 10
页数：10
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  • [1] Tuberculosis Immune Reconstitution Syndrome Among Ugandan Children
    Bakeera-Kitaka, S.
    Kekitiinwa, A.
    Dhabangi, A.
    Namulema, E.
    Maganda, A.
    Boulware, D. R.
    [J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2008, 12 : E63 - E64
  • [2] The spectrum of latent tuberculosis: rethinking the biology and intervention strategies
    Barry, Clifton E., III
    Boshoff, Helena I.
    Dartois, Veronique
    Dick, Thomas
    Ehrt, Sabine
    Flynn, JoAnne
    Schnappinger, Dirk
    Wilkinson, Robert J.
    Young, Douglas
    [J]. NATURE REVIEWS MICROBIOLOGY, 2009, 7 (12) : 845 - 855
  • [3] Pleural Tuberculosis in Patients with Early HIV Infection Is Associated with Increased TNF-Alpha Expression and Necrosis in Granulomas
    Bezuidenhout, Juanita
    Roberts, Teri
    Muller, Liesel
    van Helden, Paul
    Walzl, Gerhard
    [J]. PLOS ONE, 2009, 4 (01):
  • [4] Biomarkers of HIV immune reconstitution inflammatory syndrome
    Bonham, Shuli
    Meya, David B.
    Bohjanen, Paul R.
    Boulware, David R.
    [J]. BIOMARKERS IN MEDICINE, 2008, 2 (04) : 349 - 361
  • [5] Pediatric HIV immune reconstitution inflammatory syndrome
    Boulware, David R.
    Callens, Steven
    Pahwa, Savita
    [J]. CURRENT OPINION IN HIV AND AIDS, 2008, 3 (04) : 461 - 467
  • [6] Tuberculosis-Associated Immune Restoration Syndrome in HIV-1-Infected Patients Involves Tuberculin-Specific CD4 Th1 Cells and KIR-Negative γδ T Cells
    Bourgarit, Anne
    Carcelain, Guislaine
    Samri, Assia
    Parizot, Christophe
    Lafaurie, Matthieu
    Abgrall, Sophie
    Delcey, Veronique
    Vicaut, Eric
    Sereni, Daniel
    Autran, Brigitte
    [J]. JOURNAL OF IMMUNOLOGY, 2009, 183 (06) : 3915 - 3923
  • [7] Human immunodeficiency virus type 1 (HIV-1) quasispecies at the sites of Mycobacterium tuberculosis infection contribute to systemic HIV-1 heterogeneity
    Collins, KR
    Quiñones-Mateu, ME
    Wu, M
    Luzze, H
    Johnson, JL
    Hirsch, C
    Toossi, Z
    Arts, EJ
    [J]. JOURNAL OF VIROLOGY, 2002, 76 (04) : 1697 - 1706
  • [8] Immune reconstitution inflammatory syndrome in HIV-Infected patients receiving Antiretroviral therapy - Pathogenesis, clinical manifestations and management
    Dhasmana, Devesh J.
    Dheda, Keertan
    Ravn, Pernille
    Wilkinson, Robert J.
    Meintjes, Graeme
    [J]. DRUGS, 2008, 68 (02) : 191 - 208
  • [9] HIV-1/Mycobacterium tuberculosis Coinfection Immunology: How Does HIV-1 Exacerbate Tuberculosis?
    Diedrich, Collin R.
    Flynn, JoAnne L.
    [J]. INFECTION AND IMMUNITY, 2011, 79 (04) : 1407 - 1417
  • [10] For better or for worse: the immune response against Mycobacterium tuberculosis balances pathology and protection
    Dorhoi, Anca
    Reece, Stephen T.
    Kaufmann, Stefan H. E.
    [J]. IMMUNOLOGICAL REVIEWS, 2011, 240 : 235 - 251
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