Process Intensification via Reaction Telescoping and a Preliminary Cost Model to Rapidly Establish Value

Process intensification via reaction telescoping has recently been demonstrated in our research laboratories. The improved process is significantly streamlined; 1 intermediate isolation vs 2, 24 workup and purification unit operations vs 49, and a batch cycle time of 116 h vs 177 h are the key improvements realized. A preliminary cost model was developed to establish the value generated, which predicts a >50% reduction in the total cost to manufacture 1 kg of the product. This cost model can serve as a preliminary method for rapidly establishing the value of process intensification in the manufacture of fine and specialty chemicals.